Pacific Northwest Research Institute

One internship. One mentor. Two remarkable careers. Former PNRI interns Kate Helle and Lidiia Gagarina are now pursuing careers in #medicine and #gene therapy after finding inspiration and #mentorship in the Carvalho Lab @CMBCarvalho. Read their story: bit.ly/4eQBNrc

A contagious #cancer triggered a severe outbreak in soft-shell clams in Puget Sound. In a new @PNASNews study, Dr. Michael Metzger and team found evidence that the disease came from Atlantic Coast populations and developed an eDNA tool to track its spread: bit.ly/4g4mP3p

Understanding the #genome isn't always about finding one wrong note. Sometimes it's about hearing the whole symphony. Learn how PNRI researchers are uncovering hidden causes of disease. @CMBCarvalho. Read more: bit.ly/4nVblkx
#raredisease #geneticvariants

New coverage in The Scientist highlights Dudley Lab research showing that two damaging variants don’t always make disease worse — they often restore protein function. Findings could reshape how #genetic risk is interpreted, especially for #raredisease. bit.ly/4rdvgfm

Two genetic “wrongs” can sometimes make a right. New PNRI research shows that pairs of damaging variants can restore normal protein function—challenging assumptions in #genetics and opening doors to more accurate rare disease diagnosis. Published in PNAS. bit.ly/4qKEGhK