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Pascal Unger

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@PascalUnger

I back technical founders at inception || Co-Founder & GP @focal_vc || 3 month founder residency: southbound.focal.vc
Miami, FL focal.vc Joined April 2019
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Pascal Unger Verified account @PascalUnger
Anyone can build now. Few dare to aim big enough.

That's why we're launching Southbound W27 by @thelabmiami & @focal_vc today.

Code is now cheap, abundant, and written by machines. What’s scarce is real ambition, intelligence, compute, and distribution.

It's what Southbound is built for: To help the best technical founders think bigger and move faster from day 1.

We're now opening applications to the second cohort of our winter residency.

If you want to:
- Escape the cold
- Work on an absurdly ambitious problem, surrounded by your best technical peers
- Get weekly mentorship by unicorn founders
- Funding on an uncapped MFN SAFE (vs giving up 7%)
- $1M in perks and compute
- and much more

... then join us in Miami from Jan 11 - Apr 11 2027.

Southbound is:
- Limited to 10 spots (teams or solo founders)
- Fully in person in Miami
- 7 days / week in office.

The cohort is small by design: Instead of being a number in a big batch, you get a hand-picked group of your best peers, weekly dinners with unicorn founders, and real time with focal’s GPs.

Rolling admission until all 10 spots are filled / applications close Dec 11.

Apply asap (link in comments!)

@ayalstern | @DanielDarling | @amiine_afia | @wynwoodceo | @SydneyWasi
1:50
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Pascal Unger Verified account @PascalUnger
We’re a step closer to the 1 person biotech
filippkramer Verified account @fvkramer 2d
The one-person biotech is about more than team size. It's about where the industry is heading.

As biotech becomes more distributed and accessible, deciding what to build, how, and when becomes increasingly important.

Today we're introducing Praxis, our integrated biotech development platform.

From scientific hypotheses and clinical strategy to CRO selection and financing, we're building the infrastructure for a new generation of biotech companies.

We're opening applications for our first 20 companies.

unobio.com/praxis
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Pascal Unger Verified account @PascalUnger
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OpenAI Verified account @OpenAI Oct 23
Over the past several months, we have substantially hardened the security of our research training environment. We’ve removed live internet access for all frontier models during training and built an offline world for them to use instead—a cached version of the web where they can still learn to browse, search, and use applications.

On September 20, after a model exploited a DNS misconfiguration to find a way outside of this offline world, we paused frontier training to strengthen containment further. We assembled teams of agents, powered by our most cyber-capable models, and tasked them with finding weaknesses in our research environments.

While they found no route to the internet they could easily exploit while concealing their activity from our monitors, they did find zero-day vulnerabilities, virtual machine escapes, and hardware side-channels for communication between agents. We used their discoveries to further strengthen our defenses and contribute fixes to open-source software.

After strengthening our containment architecture, we resumed our frontier RL training and inference on October 1. We’ve reserved substantial compute for continuous red-teaming, and made high-compute red-teaming part of the safety cases we use to decide whether frontier training and evaluation can proceed securely.

openai.com/index/securing…
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Pascal Unger Verified account @PascalUnger
Eito Miyamura | 🇯🇵 Verified account @Eito_Miyamura Oct 21
Lots of Security incidents today, here's some practical tips for those who just wanna protect yourself:

1) UPDATE EVERYTHING - main targets are:
a) Browsers - Chrome, Safari, Firefox
b) OS: : Settings -> General -> software update; Linux: sudo apt update && sudo apt upgrade; Windows: I think there's a button. Do this for any remote home servers & Openclaw/hermes boxes
c) Phones: Update it all
d) Desktop apps (Slack, Cursor, Discord, etc)

2) Limit web browsing this week: Stay within walled gardens (twitter, youtube, etc); don't click random links this week. Just wait until the patches go through. Do step 1 again after a week.

3) Avoid untrusted Wifi networks until your devices are updated

4) Stay vigilant about phishing emails offering "certificate fixes" or fraud updates

5) Have an iPhone 11-16? TURN BLUETOOTH OFF for the time being until apple patches come through.

6) Code/Dev: UPDATE ALL YOUR REPOS - @charliermarsh has already updated uv 0.13.4 which reacts to the eMudra incident for uv (Python), Typesript according to Claude has equivelant. Tell your agents to go and update all your active repos to update package manager across uv, npm, bun, cargo, etc etc

What advice did I miss?
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