Laboratory of Molecular Pathogenetics

@PavlinkovaLab

We study transcriptional regulation during the development of the inner ear, heart, and pancreas.
#development #innerear #heart #pancreas #diabetes

BIOCEV, Vestec, Czechia tinyurl.com/PavlinkovaLab Joined February 2020

34 Following 101 Followers 12 Posts

Latest posts 5

Laboratory of Molecular Pathogenetics @PavlinkovaLab Feb 17, 2022

Fresh article @FrontCellDevBio from our lab: Early Deletion of #Neurod1 Alters Neuronal Lineage Potential and Diminishes #Neurogenesis in the #InnerEar
doi.org/10.3389/fcell.…

Laboratory of Molecular Pathogenetics @PavlinkovaLab Jun 23, 2021

Happy to share our first publication in the pancreas field with you: #NEUROD1 Is Required for the Early α and β Endocrine #Differentiation in the #Pancreas mdpi.com/1160522 via @MDPIOpenAccess, and stay tuned, more is about to come!

Laboratory of Molecular Pathogenetics @PavlinkovaLab Jun 5, 2021

This weekend, our lab has returned to the crime scene in South Moravia for our annual #teambuilding event.

Laboratory of Molecular Pathogenetics @PavlinkovaLab Jan 11, 2021

Fresh review now available in a special issue of Int. J. Mol. Sci: Molecular Aspects of the Development and Function of Auditory Neurons. International Journal of Molecular Sciences. 2021; 22(1):131. doi.org/10.3390/ijms22…

www.mdpi.com Molecular Aspects of the Development and Function of Auditory Neurons This review provides an up-to-date source of information on the primary auditory neurons or spiral ganglion neurons in the cochlea. These neurons transmit auditory information in the form of electric...

Laboratory of Molecular Pathogenetics @PavlinkovaLab Jan 11, 2021

New article from our inner ear development project was published! Combined Atoh1 and Neurod1 Deletion Reveals Autonomous Growth of Auditory Nerve Fibers. Mol Neurobiol 57, 5307–5323 (2020). rdcu.be/cdm80

Schematics of structural changes in the cochlea induced by
expressional alternations of Neurod1 and/or Atoh1 as a combination of
cues for guiding neuronal axons to their target sensory organs. In the
control cochlea, spiral ganglion (SG) neurons are radially connected
(RF, radial fibers, red) with a single ending to IHC (10-20 neurons/
1IHC). The loss of Atoh1 results in a flat epithelium without any sensory
cells and innervation, reduction of SG neurons, and retraction of radial
fibers. Absence of Neurod1 correlates with reduced number of SG neurons,
a loss of apex-base and vestibular fiber segregation, multiple endings
of a single neuron to HCs, and the disorganized epithelium in the
apex of Neurod1CKO. In Atoh1/Neurod1CKO neuronal fibers ramify
inside the flat epithelium that replaces the organ of Corti. Magenta color
depicts neurons and fibers in the cochlea labeled by the dye application to
the vestibular end organs.