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🟧PCSK9 INHIBITORS.
PCSK9 inhibitors are cholesterol-lowering drugs used to reduce LDL cholesterol levels, particularly in patients who need additional LDL reduction despite statin therapy or who cannot tolerate statins.
Key examples:
◽️evolocumab
◽️alirocumab
🟧MECHANISM OF ACTION.
PCSK9 inhibitors block the PCSK9 protein from degrading LDL receptors in the liver, increasing the number of available receptors that can remove LDL cholesterol from the bloodstream and thereby lowering LDL levels.
🟧SIDE EFFECTS.
◽️nasopharyngitis
◽️injection-site reactions
◽️influenza
🟧DOSAGE & ADMINISTRATION.
Once every two weeks subcutaneous injections, or once monthly:
The recommended dosage of alirocumab is 75 mg once every 2 weeks administered SC, or 300 mg once every 4 weeks (monthly).
The recommended dosage of evolocumab is either 140 mg every 2 weeks or 420 mg once monthly administered SC.
🟧BRAND NAMES.
◽️Praluent (alirocumab)
◽️Repatha (evolocumab)
PCSK9 inhibitors are cholesterol-lowering drugs used to reduce LDL cholesterol levels, particularly in patients who need additional LDL reduction despite statin therapy or who cannot tolerate statins.
Key examples:
◽️evolocumab
◽️alirocumab
🟧MECHANISM OF ACTION.
PCSK9 inhibitors block the PCSK9 protein from degrading LDL receptors in the liver, increasing the number of available receptors that can remove LDL cholesterol from the bloodstream and thereby lowering LDL levels.
🟧SIDE EFFECTS.
◽️nasopharyngitis
◽️injection-site reactions
◽️influenza
🟧DOSAGE & ADMINISTRATION.
Once every two weeks subcutaneous injections, or once monthly:
The recommended dosage of alirocumab is 75 mg once every 2 weeks administered SC, or 300 mg once every 4 weeks (monthly).
The recommended dosage of evolocumab is either 140 mg every 2 weeks or 420 mg once monthly administered SC.
🟧BRAND NAMES.
◽️Praluent (alirocumab)
◽️Repatha (evolocumab)