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Michiyuki Matsuda

@Phogemon

A biologist specialized in fluorescence microscopy, oncogene research, and experimental pathology.
lif.kyoto-u.ac.jp/dynamiclivings… Joined August 2020
47 Following 261 Followers 46 Posts

Latest posts 5

Michiyuki Matsuda @Phogemon
Excellent work from the Igaki lab. Free ribosomal proteins that are not incorporated into ribosomes are degraded by the ubiquitin degradation system, preventing cellular stress from excess unused proteins.
jstage.jst.go.jp/article/csf/49…
www.jstage.jst.go.jp In vivo evidence for homeostatic regulation of ribosomal protein levels in Drosophila The ribosome is a molecular machine essential for protein synthesis, which is composed of approximately 80 different ribosomal proteins (Rps). Studies …
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Michiyuki Matsuda @Phogemon
We are pleased to announce our latest paper published in eLife. Here, we have visualized that confluent MDCK cells secrete PGE2 in a manner dependent on stoshastic calcium spikes. elifesciences.org/articles/86727…
elifesciences.org Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-r... Prostaglandin E2-mediated radial spread of PKA activation, caused by calcium transients, is a novel mode of intercellular communication in living mice.
0 replies 8 reposts 31 likes 4.7K views View on X
Michiyuki Matsuda @Phogemon
We report the visualization and quantification of PGE2 secreted by epithelial cells. A single calcium spike causes a cell to secrete 0.25 fmol PGE2, or 150 million PGE2, which activates PKA in 1000 neighboring cells. jstage.jst.go.jp/article/csf/48…
www.jstage.jst.go.jp Visual quantification of prostaglandin E2 discharge from a single cell Calcium transients drive cells to discharge prostaglandin E2 (PGE2). We visualized PGE2-induced protein kinase A (PKA) activation and quantitated PGE2 …
0 replies 8 reposts 28 likes 3.4K views View on X
Michiyuki Matsuda @Phogemon
A mechanism to drive multivesicular bodies (MVBs) to exosome release has been reported by Mitsunori Fukuda's group. Good job!
jstage.jst.go.jp/article/csf/ad…
www.jstage.jst.go.jp VAMP5 and distinct sets of cognate Q-SNAREs mediate exosome release Small extracellular vesicles (sEVs) are largely classified into two types, plasma-membrane derived sEVs and endomembrane-derived sEVs. The latter type …