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Phys Reports
@PhysRep
An online only, open access journal publishing peer-reviewed research across all areas of physiology. A collaboration between The PhySoc and the APS.
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@PhysRep: #Acetazolamide, an inhibitor of carbonic anhydrase that can induce arteriolar #vasodilation, is shown in this pilot study of acute #braininjury patients to increase brain #oxygenation and #intracranial #pressure.
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@Hypoxia @CerebralVasculature
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@Hypoxia @CerebralVasculature
physoc.onlinelibrary.wiley.com Effects of acetazolamide on intracranial pressure and brain tissue oxygenation on patients with... Administration of acetazolamide in patients with acute brain injury resulted in a significant increase in brain oxygenation, accompanied by a concurrent rise in ICP and flow velocities, suggesting... @PhysRep: Hearts of #pyruvatekinase M2 KO mice show increased oxidative stress, #inflammation and #fibrosis after #myocardial #infarction, implicating a protective role of #PKM2.
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@Cardiovascular
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@Cardiovascular
physoc.onlinelibrary.wiley.com Loss of PKM2 dysregulates inflammatory signaling in the infarcted murine heart Inflammation and a metabolic shift from oxidative metabolism to glycolysis are common in the ischemic heart, the latter partly controlled by pyruvate kinase (muscle, PKM). We previously identified... @PhysRep: In this new paper, #thoracic load carriage in hypoxic conditions to mimic high #altitude is shown to increase physiological strain and interfere with compensatory responses to #hypoxia in healthy males.
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@Respiratory #MuscleFatigue #Hemodynamics
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@Respiratory #MuscleFatigue #Hemodynamics
physoc.onlinelibrary.wiley.com Thoracic load carriage impairs the acute physiological response to hypoxia in healthy males To assess the impact of thoracic load carriage on the physiological response to exercise in hypoxia. Healthy males (n = 12) completed 3 trials consisting of 45 min walking in the following conditio... @PhysRep: This new report shows that regulation of miRNA-1, a #skeletal #muscle specific #miR, is necessary for mechanical overload-induced muscle #hypertrophy in a mouse model
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#myotwitter
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#myotwitter
physoc.onlinelibrary.wiley.com miRNA‐1 regulation is necessary for mechanical overload‐induced muscle hypertrophy in male mice Schematic representation of mice subjected to mechanical overload (via synergist ablation) following miR-1 overexpression to determine its role in skeletal muscle hypertrophy. Muscle tissue samples...