Profluent

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@ProfluentBio

Grounded in nature, authored by AI

Emeryville, CA profluent.bio Joined September 2022

0 Following 4.2K Followers 191 Posts

Latest posts 5

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Profluent @ProfluentBio Nov 19, 2025

Today we’re announcing $106M in new funding led by Altimeter Capital and Bezos Expeditions. This brings our total to $150M to scale our frontier AI models which make biology programmable.

Our frontier models have generated functional proteins (Nature Biotech, 2023), created the first CRISPR system designed from scratch (Nature, 2025), and showed clear scaling behavior (NeurIPS spotlight, 2025).

The opportunities ahead are unimaginable. If you’re excited by shaping the future of biology – join us in pushing the science forward.

Forbes: forbes.com/sites/amyfeldm…
Press Release: businesswire.com/news/home/2025…
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Nature Biotech, 2023: nature.com/articles/s4158…
NeurIPS spotlight, 2025: biorxiv.org/content/10.110…
Nature, 2025: nature.com/articles/s4158…

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Profluent @ProfluentBio Oct 12

Profluent is a finalist for the Emerging Innovator of the Year award at the 23rd Annual Pantheon Awards @CALifeSciences

Frontier AI for biology, built in California.

California Life Sciences (CLS) @CALifeSciences Oct 8

Meet the 2026 Pantheon Award winners 🏆🌊

Through their transformative discoveries, breakthrough technologies, and steadfast leadership, this group of innovators, companies, and institutions have advanced California's life sciences industry and made exceptional contributions to improve lives around the world. We're looking forward to honoring @Genentech, Ziad Obermeyer, MD, @NOETIK_ai, @RevMedicines, Teal Health, @SD2org, and Catriona Jamieson, MD, PhD, this November.

🌟 Plus, we'll be announcing the winner of our Emerging Innovator of the Year award live during the ceremony. Join us in San Francisco and be the first to find out who it is 🔗 bit.ly/4jd7S0n

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Profluent @ProfluentBio Sep 30

We’re partnering with @BioMarin to use our AI models to design novel medicines.

Our foundation models unlock proteins with new and improved functions by drawing on the world's largest dataset of unique protein sequences (115B and counting): Profluent’s Protein Atlas

BioMarin will screen designs we generate and advance the strongest into preclinical testing. Looking forward to what AI can unlock for patients!

Profluent @ProfluentBio Aug 12

Stephen Nayfach, our Head of Bioinformatics and Platform R&D, is at @CSHL this week for the Genome Engineering: CRISPR Frontiers event. Find him and say hi if you're there! 👋

He's giving a talk on using our AI models to design CRISPR-Cas9 variants for base editing ("Programming PAM Specificity for Mutation-Specific Base Editor Design") and also chairing the session "CRISPR Technologies I"

Profluent @ProfluentBio Jul 30

The Profluent team is heading to Summer RosettaCon next week! Find @jeffruffolo, @richardwshuai, @ShiakiMinami, and Alex Hoffnagle and say hi 👋

You can hear Richard talk about E1, our encoder model, on Thur at 1:30pm (“E1: Retrieval-Augmented Protein Encoders for Fitness and Structure Prediction”) and Alex share his work on our AI-designed base editors on Mon at 7:30pm (“Design of Programmable Base Editors with Protein Language Models”).