Raffaele Cacciaglia

Honored and grateful to the @FundacioJoanOro for awarding us a predoctoral fellowship (FI 2025) to support a PhD on brain connectivity in preclinical AD, probing cognitive resilience & vulnerability, within our Neuroplasticity & Connectomics team at @BarcelonaBeta

New study from our group: the CSF p-tau/Aβ42 ratio tracks early Alzheimer’s pathology in cognitively unimpaired individuals. Its effects on Aβ deposition and brain structure vary by age, sex, and APOE-ɛ4, highlighting the need for personalized prevention. tinyurl.com/mrw3dj2x

Excited to share our study @fpmaragall showing that CSF amyloid predicts medial temporal atrophy & cognitive decline in two cohorts of cognitively intact individuals. Findings highlight the need to recruit asymptomatic individuals for preclinical trials! bit.ly/4gvK2rv

It's been a true pleasure and an honor to present our brain connectivity data in preclinical Alzheimer's at the #EuroPAD symposium, in the context of @IMI_EPAD and @IMI_AMYPAD. Thanks to @FBarkhof and @LECollij for organizing this fantastic event! More to come next year!!

CSF sTREM2 and YKL-40 differentially modulate the association between soluble and fibrillar amyloid early in the AD continuum. If you want to know more, join me tomorrow at poster P4-386 #AAIC2023 #ENDALZ #ISTAART @BarcelonaBeta