Robert Avram

EXCITED to share the release of two foundation models for electrocardiogram interpretation in @ehj_ed We built DeepECG-SL and DeepECG-SSL, two open-source ECG foundation models trained on >1M ECGs and validated across 11 external datasets (881K ECGs).
🔗 academic.oup.com/eurheartj/adva…

SYNCHRONIZE-CVOT #AHA26: survodutide clears CV safety bar.

Glucagon/GLP-1 agonist vs placebo, ~5,500, obesity + high risk.
5-pt MACE HR 0.89 (0.67–1.18), noninferior.
Weight ↓13.7% vs 2.0%.

Safety trial, not proof of benefit. ~20% quit for GI effects. ajmc.com/view/survoduti…

ATTAIN-OSA #AHA26: a daily pill for sleep apnea?

Oral orforglipron cut AHI by ~18 vs ~5 events/h with placebo at 52 wk (n=712, OSA + excess weight).

Weight ↓10–11%, SBP ↓~7 mm Hg.

Caveats: 1 yr, no CV outcomes, likely weight-driven.

newsroom.heart.org/news/daily-ora…

Weee less drugs but read past non inferiority … STREAM: stopping primary-prevention statins in multimorbid adults 70+ met 2-year event-free RMST noninferiority, yet MI/stroke/death was 12.7% vs 9.2% (HR 1.38). Not a green light to stop. #ScientificSessions26 @RZubiranS

Same signal across risk groups? Not the same certainty. OCEANIC-STROKE exploratory post-hoc: no Framingham interaction (P=0.58); high-risk stroke HR 0.73, lower-risk estimates imprecise. Not new primary results. #ScientificSessions26 @RZubiranS