Science Magazine

GLP-1 receptor agonists are among the most effective treatments for obesity and other metabolic disorders. With widespread use of these drugs, it has become clear that their effects go well beyond health conditions traditionally linked to metabolism, affecting multiple other organ systems, particularly the brain.

Continued research in this field has also expanded beyond the GLP-1 receptor as a target, with the development of additional drugs and combinations to help optimize patient care.

Learn more in this special issue of Science: scim.ag/4yX17UB

Happy 159th Birthday, Marie Skłodowska Curie! What remains to be said of this scientific icon?

In the book The Elements of Marie Curie, Dava Sobel "offers a vivid narrative that uses Curie’s well-known story as scaffolding for tales of the brilliant young women who trained in her lab and became part of her scientific legacy."

Read the #ScienceBooks Review: scim.ag/4Acs9bs

"I still find the AI assistant helpful for refining routine correspondence. But I have found it can get in the way of connecting with the people closest to me." #ScienceWorkingLife scim.ag/3UCwrK7

New experiments present a rational cytokine-engineering strategy to activate immune signaling networks and provide clues about whether the cytokine IL-39 is found in the human body—a longstanding debate in #immunology. @SciSignal scim.ag/48vIWKO

A new approach to stimulating protein degradation could expand the therapeutic potential of targeted treatments for complex neurodegenerative diseases involving multiple dysfunctional proteins, according to a new study in Science. scim.ag/4iASGIA