Science Translational Medicine

In a unique human challenge study, researchers interrogate how preexisting immunity and antibodies against the four serotypes of #dengue influence viremia, T cell responses, and immune activation in a safe and controlled setting. @CamilaOdio @NIH scim.ag/3W4jxVS

By analyzing a massive collection of #TcellReceptor chains from 150,000+ patient samples, researchers develop a pipeline to accelerate the discovery and validation of public T cell receptors for immunotherapeutic design. @BioNTech_Group scim.ag/48BezCN

Clinical trials of an anti-HIV antibody offer clues to prevent viral escape and resistance, a massive dataset accelerates the discovery of T cell receptors for future cancer therapeutics, and more this week in #ScienceTranslationalMedicine. scim.ag/4sGXxwj

A new analysis of mice and samples from patients with #psoriasis identifies CHI3L2 as a central driver of the condition, showing that it propels an inflammatory loop by reprogramming phospholipid metabolism in keratinocytes. @XJTU_China scim.ag/4yYjMzC

New work links synovial inflammation in #osteoarthritis to a signaling axis involving CD74 and ENO2 that reprograms macrophages into an inflammatory and metabolically active state—but shows these cells can be targeted to treat the disease in mice. scim.ag/4A4r7yx