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1/ Our latest - @JAMAOncology Viewpoint! Ablative radiotherapy has a dual effect on metastatic cancer that changes how we should interpret progression after treatment.
Sean Pitroda, M.D.
@SeanPitroda
Professor @UChicago @LudwigCancer investigating oligometastatic disease & radiation/immunotherapy interactions
185 Following 820 Followers 442 Posts
Latest posts 5
Spatiotemporal control of CAR-T cell TNF release via tumor-targeted irradiation
nature.com/articles/s4301…
Congrats @rweichselbaum @KunleOdunsiMD @UCCancerCenter @UChicagoRadonc @Ludwig_Cancer
nature.com/articles/s4301…
Congrats @rweichselbaum @KunleOdunsiMD @UCCancerCenter @UChicagoRadonc @Ludwig_Cancer
www.nature.com Spatiotemporal control of CAR-T cell TNF release via tumor-targeted irradiation Nature Cancer - Masoumi et al. engineered CAR-T cells with a radiation-inducible promoter controlling the expression and local release of the cytokine TNF upon tumor irradiation. Out in @Cancer_Cell: TET2 inhibition reprograms myeloid cells to potentiate radiotherapy and curb metastasis
sciencedirect.com/science/articl…
@rweichselbaum
@UChicagoRadonc
@UChicagoMed
@Ludwig_Cancer
@hhmi_science
sciencedirect.com/science/articl…
@rweichselbaum
@UChicagoRadonc
@UChicagoMed
@Ludwig_Cancer
@hhmi_science
1/5 Our recent study (nature.com/articles/s4158…) identified AREG, a radiation-induced factor that can drive the growth of unirradiated metastases after SABR. 🧵
www.nature.com Radiation-induced amphiregulin drives tumour metastasis Nature - Radiotherapy induces expression of the EGFR ligand amphiregulin, which promotes metastasis growth at remote sites in mouse models and human patients by shifting myeloid cells towards an... Congrats to @rweichselbaum and team on their @ScienceAdvances paper: engineering probiotic Bifidobacterium as a "bugs as drugs" platform to deliver tumor-targeted IL-2 and boost RT, chemo, and immunotherapy responses in pancreatic cancer. @UChicagoMed
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…
www.science.org Engineered probiotic Bifidobacterium for tumor-targeted pancreatic cancer therapy Engineered probiotic Bifidobacterium secretes effector T cell–boosting IL-2 variant to reduce pancreatic tumor growth in mice.