In vitro, multiple #DNA_repair proteins Ku load from DNA ends on linear DNA, eventually covering it. Yet, in cells, only one Ku is found per DNA end at double-strand breaks. What restricts Ku entry on chromatin? doi.org/10.1016/j.celr…
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In 2022 we discovered that some cytotoxic lipids are prodrugs bioactivated by hHSD17B11. Here we develop the PAC series, equally potent but allowing more structural variations + more stable in biological media, and analyzed its safety profile in vivo doi.org/10.1021/acs.jm…
Inositol-hexaphosphate (IP6) stimulates #NHEJ #DNA_Repair, but how? In this collaborative work, we report several structures of the Ku-IP6 complex and reveal that IP6 increases NHEJ efficiency by enhancing Ku association to XLF and to DNA.
doi.org/10.1093/nar/gk…
doi.org/10.1093/nar/gk…
academic.oup.com Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization... Abstract. The classical Non-Homologous End Joining (c-NHEJ) pathway is the predominant process in mammals for repairing endogenous, accidental or programme Check-out our new publication in @ScienceAdvances where we decipher at the structural and functional levels how PAXX and XLF can interact simultaneously with Ku to promote DNA end synapsis and proficient #NHEJ #DNA_repair doi.org/10.1126/sciadv…
