ShenoyLab

1/6 We built a sequencing-informed polymer model that integrates STORM, Hi-C, and RNA-seq to reveal how HC domains — especially their boundaries —regulate gene expression during drug treatment, microenvironmental changes, and cell fate transitions. doi.org/10.1038/s41467…

New preprint on integrating biophysical computational modeling with high-resolution imaging to predict how epigenetics and chromatin-lamina interaction energetics regulate the size and shape of lamina-associated domains (LADs)! biorxiv.org/content/10.110…

New paper in @CommsBio! We show that Vimentin is a key regulator of cell mechanosensing. Depending on the stiffness of the microenvironment, disrupting Vimentin can decrease or increase actomyosin-contractility. nature.com/articles/s4200…

New paper in Nature Communications! Our joint theory and Hi-Res imaging study shows how inhibiting transcription alters 3D chromatin organization by reducing loop extrusion thus increasing the size of heterochromatin domains in multiple cell lines.
nature.com/articles/s4146…

Excited to share our preprint on "mechano-metabolism," predicting how cancer cells adapt ATP dynamics in 3D environments. Cells consume more ATP and effectively restore ATP reserves in stiffer matrices through AMPK activation. @CEMB_STC, @PennEngineers
biorxiv.org/content/10.110…