Shuke Xiao 肖舒克

@Shuke_Xiao

K99/R00 Postdoc fellow: @longlabstanford @StanfordPath @Stanford_ChEMH PhD: @CarlsonLab_Yale #FirstGen
Personal Website shuke.skxiao.workers.dev

Stanford, CA Joined December 2015

856 Following 316 Followers 286 Posts

Latest posts 5

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Shuke Xiao 肖舒克 @Shuke_Xiao Sep 30

Glad to share a new story on how Lac-Phe enters the bloodstream from the gut: a monocarboxylate transporter MCT6 does the job! Interestingly, within the same SLC16 family, MCT1 transports lactate, and MCT10 transports Phe. Thanks to all collaborators who made this work possible!

Long Lab @longlabstanford Sep 30

Lac-Phe is an exercise💪 and metformin💊 inducible blood-borne metabolite that suppresses appetite. How does Lac-Phe get into circulation? New from @Shuke_Xiao: a transporter deorphanization story that links local cellular metabolism to systemic activity:
biorxiv.org/content/10.648…
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Shuke Xiao 肖舒克 @Shuke_Xiao Oct 24

So much fun learning from the Leinwand lab about the pythons! Thank you for hosting us!!!!

Long Lab @longlabstanford Oct 23

A big thank you to Leslie Leinwand lab for hosting @Shuke_Xiao @ssiipei this week @CUBoulder. Learning more about 🐍 husbandry to get our own colony up and going @Stanford_ChEMH

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Shuke Xiao 肖舒克 @Shuke_Xiao Oct 22

Thanks for all the colleagues and collaborators who made this possible!

Long Lab @longlabstanford Oct 22

Our work deorphanizing MCT6 as the missing gut Lac-Phe transporter is out today @CellCellPress: local gut lactate metabolism influences gut-brain crosstalk, and also explains metformin’s effects on body weight. Congratulations to @Shuke_Xiao @alanshtung!
cell.com/cell/fulltext/…
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Shuke Xiao 肖舒克 @Shuke_Xiao Sep 2

Really excited to visit CMH! Really happy to share our work on SLC(solute carrier) in SLC (Salt Lake City).

University of Utah Center for Metabolic Health @UtahCMH Sep 1

Happening tomorrow! Don't forget to join us at our CMH Rising Stars!
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Shuke Xiao 肖舒克 @Shuke_Xiao Aug 18

Really exciting news! Lac-Phe mimetic can act as a leptin sensitizer! Many puzzles remain and much more to explore!!!!!!

Long Lab @longlabstanford Aug 18

A remarkably fast timeline:
2022: our lab @veronical1411 first discovers Lac-Phe as an exercise-inducible anorexigenic metabolite
2024: @Shuke_Xiao @lynchielydia Lac-Phe also mediates metformin-associated weight loss
2026: an oral Lac-Phe mimetic in human completes phase 1 trial
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