Simon Phipps

@SimonPhipps14

Head of Respiratory Immunology, QIMR Berghofer MRI.

Brisbane, Queensland Joined September 2019

157 Following 44 Followers 42 Posts

Latest posts 5

Thanks to all our generous collaborators for supporting this project. Thanks also to the editorial team at Cell and the reviewers who helped improve the final copy.

Cell @CellCellPress Aug 3

Now online! Milk osteopontin alters the infant microbiome to drive DC hematopoiesis and disease tolerance dlvr.it/TTrKc8
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Simon Phipps @SimonPhipps14 Aug 3

Wonderful to see our paper online today at Cell. Thanks to all the coauthors and congrats to Daniel, well deserved!

Daniel Ryan Howard Verified account @danielrhoward Aug 3

Thrilled to share my first first-author paper published online today in @CellCellPress!🎉

In this study, we show that osteopontin protects from lower respiratory infections by altering the neonatal gut microbiome.

🔗 Read here: cell.com/cell/fulltext/…

Let's dive in! 🧵 1/
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Simon Phipps @SimonPhipps14 Nov 28, 2024

Remarkably, the beneficial effects of DP2 antagonism are mediated by the activation of DP1, which requires endogenous PDG2, which is suppressed by steroids! Less is more!

Simon Phipps @SimonPhipps14 Nov 28, 2024

DP2 antagonists ameliorate exacerbation severity and reverse airway smooth muscle remodelling in asthma. But this effect is lost when co-administered with corticosteroids, providing an explanation for the lack of efficacy in Phase III.

Simon Phipps @SimonPhipps14 Nov 28, 2024

Latest paper from the lab just out @natcomms rdcu.be/d1xmn Thanks to all involved! 👏
Simon