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Wiep Klaas Smits

@SmitsLab

Assoc. prof. @LUMC_Leiden/CMAT. Cdiff, DNA replication, AMR, microbiome, anaerobes. Clostpath SC. Education officer ESGCD. Also: @smitslab.bsky.social
Leiden, Nederland lumc.nl/smits Joined August 2015
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Wiep Klaas Smits @SmitsLab
[🔔] Publication alert! The CloDiCo trial is now published in @NatureComms @NaturePortfolio (Editor's choice!). This is the work of an amazing team, and led by PhD student Annefleur Hensen. Check out this thread [👇] for a summary of the study.
nature.com/articles/s4146…
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www.nature.com Experimental human colonisation with non-toxigenic Clostridioides difficile: a placebo-controlled... Nature Communications - Experimental human colonisation with non-toxigenic Clostridioides difficile shows that antibiotic-mediated microbiota disruption, particularly prolonged treatment, increases...
Wiep Klaas Smits @SmitsLab
Direct regulation of a tRNA modification enzyme by ppGpp links stress signaling to translational control and biofilm development | Science Advances science.org/doi/10.1126/sc… - wonderful work from the Wang lab in Madison.
www.science.org Direct regulation of a tRNA modification enzyme by ppGpp links stress signaling to translational... Transfer RNA (tRNA) modifications influence decoding efficiency and translational fidelity, yet how they are integrated into bacterial signaling networks remains poorly understood. Here, we identify...
Wiep Klaas Smits @SmitsLab
Specific plasmid profiles of Clostridium butyricum associated with grouped cases of necrotizing enterocolitis tandfonline.com/doi/10.1080/22…
www.tandfonline.com Specific plasmid profiles of Clostridium butyricum associated with grouped cases of necrotizing... Necrotizing enterocolitis (NEC) is an unpredictable condition that is commonly encountered in neonatal intensive care units. NEC considered one of the most severe gastrointestinal diseases affectin...
Wiep Klaas Smits @SmitsLab
A host-directed virulence factor of Clostridium perfringens is modulated by gut commensal strains tandfonline.com/doi/full/10.10…
www.tandfonline.com A host-directed virulence factor of Clostridium perfringens is modulated by gut commensal strains In a healthy host, the residential microbes help regulate the growth of pathobionts, which are common members of the human gut microbiome, preventing them from causing diseases, including infection...