The Snedeker Lab

@SnedekerLab

The twitter account of Prof. Snedeker's Laboratory for Orthopaedic Biomechanics at D-HEST @ETH_en, @uzh_news_en and @DerBalgrist

Zurich, Switzerland orthobiomech.ethz.ch Joined July 2017

167 Following 596 Followers 104 Posts

Latest posts 5

The Snedeker Lab @SnedekerLab Apr 29

Out today in Nature Communications: @Amro_Hussien shows that tendon fibrosis in systemic sclerosis is mechanically gated.

We link elevated matrix tension to myofibroblast activation, suppressed collagen transcription, and rewired stromal–immune crosstalk.
nature.com/articles/s4146…

www.nature.com Mechanical gating of tendon fibrogenic transcription in systemic sclerosis Nature Communications - A tunable tendon-like mechano-culture system shows that matrix tension drives myofibroblast activation in systemic sclerosis, while immune cells override tension-mediated...

The Snedeker Lab @SnedekerLab Apr 28

Submolecular modulation of PIEZO1 mechanotransduction with wireless ta... sciencedirect.com/science/articl… ☝️💪

The Snedeker Lab @SnedekerLab Jan 11

HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment | Science Translational Medicine science.org/doi/10.1126/sc…

Important work with @KatrienDeBock, driven by @MoschiniGreta.

@snsf_ch | @derbalgrist | @UZH_en

www.science.org HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruit... HIF1α activation promotes tendinopathy, and its inhibition prevents overload-induced maladaptation, suggesting therapeutic potential.

The Snedeker Lab @SnedekerLab Oct 4, 2025

Excited to share one of our lab’s most important papers in Acta Biomaterialia! (Patrick Jaeger, lead author).
We present a 2D/3D tendon-sheet model of wound healing showing how ECM maturation and cross-linking tune tendon cell strain sensitivity.
🔗 doi.org/10.1016/j.actb…

The Snedeker Lab @SnedekerLab Feb 16, 2025

FiberLock technology achieves the long-standing challenge of bearing physiological disc loads without re-herniation. Congrats to the lead author Esteban Ongini & thanks to Sarah Gullbrand @MauckLabfor the amazing collaboration.
DOI: doi.org/10.1002/jsp2.7…

onlinelibrary.wiley.com Annulus Fibrosus Repair via Interpenetration of a Non‐Woven Scaffold Supports Tissue Integration... Current surgical management of intervertebral disc herniation inadequately addresses the risk of a recurrent herniation, in part due to limited regenerative capabilities of the disc. Here we demons...