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We are the @JeffSpraggins Research Group @VanderbiltCDB. We develop molecular imaging technologies to uncover the cellular and molecular architecture of healthy and diseased tissues.
Spraggins Lab
@SpragginsLab
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Excited to share our most recent paper by Dr. Christopher Good & our Collaborators in the @CassatLab! This work highlights our ability to map lipid dynamics between bacteria and leukocytes in S.aureus osteomyelitis. @VI4Research @VUBasicSciences cell.com/cell-chemical-…
Congrats to @angelakrusephd and the rest of the team on their work optimizing methods for spatial proteomics using MALDI IMS! Check out our paper below to see how thermal denaturation can improve peptide imaging even in unfixed, frozen tissues.
pubs.acs.org/doi/10.1021/ac…
pubs.acs.org/doi/10.1021/ac…
pubs.acs.org Thermal Denaturation of Fresh Frozen Tissue Enhances Mass Spectrometry Detection of Peptides Abstract. Thermal denaturation (TD), known as antigen retrieval, heats tissue samples in a buffered solution to expose protein epitopes. Thermal denaturati Wonderful presentation by Jacqueline Van Ardenne at the International Conference on Gram Positive Pathogens!!! #ICGP
New publication by @KateDjambazova on MALDI TIMS imaging of gangliosides in kidney s.aureus abscesses
pubs.acs.org/doi/10.1021/ja…
pubs.acs.org/doi/10.1021/ja…
pubs.acs.org MALDI TIMS IMS Reveals Ganglioside Molecular Diversity within Murine S. aureus Kidney Tissue... Abstract. Gangliosides play important roles in innate and adaptive immunity. The high degree of structural heterogeneity results in significant variability