@SquamousCscc
🚨 New preprint!View quoted post on X
CTCF Binding Site Mutations: Linking TAD Dysregulation to cSCC Progression
We show how mutations at CTCF sites drive metastasis in skin cancer.
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#Genomics #CTCF #3Dgenome #cSCC #Bioinformatics #Cancer #nswheath
researchsquare.com/article/rs-684…
www.biorxiv.org Extrachromosomal DNA in cutaneous squamous cell carcinoma is associated with increased nodal disease Extrachromosomal DNA (ecDNA) is a mechanism of oncogene amplification that occurs in many cancers and has been linked to worse patient outcomes. While ecDNA has previously been identified in cutane... 
www.mdpi.com PIK Your Poison: The Effects of Combining PI3K and CDK Inhibitors against Metastatic Cutaneous... Cutaneous squamous cell carcinoma (cSCC) is a very common skin malignancy with poor prognosis for patients with locally advanced or metastatic cSCC (mcSCC). PI3K/AKT/mTOR and cell cycle signalling... 🔬✨Dynamic dance of PI3K and CDK inhibitors against advanced cSCC. @DrJayPerry 🩸🔍 combos show promise, but the road to perfection lies in matching drug specifics to individual mutations. 🧬💊 #CancerResearch #SkinHealth 🌞👩🔬View quoted post on X
www.mdpi.com Sex as a Predictor of Response to Immunotherapy in Advanced Cutaneous Squamous Cell Carcinoma Approximately 3–5% of patients with cutaneous squamous cell carcinoma (CSCC) develop advanced disease, accounting for roughly 1% of all cancer deaths in Australia. Immunotherapy has demonstrated... 
