Structural Biology at St. Jude Children's Hospital

@StJudeStructBio

Dept. of Structural Biology, St. Jude Children's Research Hospital @StjudeResearch

Memphis, TN stjude.org/research/depar… Joined August 2019

13 Following 1.9K Followers 161 Posts

Latest posts 5

Structural Biology at St. Jude Children's Hospital @StJudeStructBio Mar 20, 2025

Beautiful work from @JunminPengLab and @Yanshen73854711 in @CellCellPress

Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: cell.com/cell/fulltext/…

Explore this amazing resource here:
yslproteomics.shinyapps.io/tissuePPT

Structural Biology at St. Jude Children's Hospital @StJudeStructBio Feb 13, 2025

Beautiful work from @JunminPengLab, presenting comprehensive proteomics and phosphoproteomics data from 5 different mouse models for Alzheimer’s disease at different ages, with comparison to human data and many insights, out in @NatureComms
Congrats @YarbroJay & all coauthors!

Jay Yarbro @YarbroJay Feb 12, 2025

Excited to share our new paper! We mapped proteomic changes in AD models, revealing shared pathways with human AD and delayed protein turnover in amyloid plaques. Read more:nature.com/articles/s4146…
@JunminPengLab @Yanshen73854711 #proteomics #MassSpec #Proteinturnover #Alzheimers
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Structural Biology at St. Jude Children's Hospital @StJudeStructBio Jan 22, 2025

Congrats to our newest faculty member, Christoph Gorgulla @StJudeResearch, and colleagues @UofT @InSilicoMeds, for work just out @NatureBiotech — using quantum computing to design small molecules that inhibit KRAS. #OpenAccess
nature.com/articles/s4158…

www.nature.com Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors Nature Biotechnology - A hybrid model combines quantum and classical approaches to generate compounds targeting the KRAS protein.

Structural Biology at St. Jude Children's Hospital @StJudeStructBio Nov 11, 2024

Beautiful work from @kriwacki in @NatureComms!
Eric Gibbs and colleagues study the interactions between nucleolar protein NPM1 and tumor suppressor p14-ARF within condensates, revealing new regulatory mechanisms.
#NMR #SAXS
nature.com/articles/s4146…

www.nature.com p14ARF forms meso-scale assemblies upon phase separation with NPM1 Nature Communications - p14ARF drives NPM1 phase separation and forms meso-scale assemblies that limit NPM1 dynamics. Here the authors show that p14ARF hydrophobic residues enhance NPM1 phase...

Structural Biology at St. Jude Children's Hospital @StJudeStructBio Oct 18, 2024

We have exciting news to share!
Abhay Kotecha (@abhaykot) is joining us as Senior Director of Technologies for Cryo-EM and Cryo-ET. We're thrilled to have him continue his great work in #CryoET, building on his innovation at @thermosciEMSpec.
Welcome to @stjuderesearch, Abhay!