1/7 Last week the Sternberg Lab welcomed ~40 junior & senior high school AP Research students from the East Meadow school district (and their incredible teachers) into our lab at Columbia University.
Sternberg Lab
@SternbergLab
News from the Sternberg lab at Columbia Univ., HHMI. Posts are from lab members and not Samuel Sternberg unless signed SHS. Posts represent personal views only.
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1/5 Telomerase has long been linked to chromosome maintenance in eukaryotes. Now, we show that telomerase-like activity is also present in bacteria, shedding new light on its ancient origins.
Excited to share that our work on DRT10 is now out in @Nature!
nature.com/articles/s4158…
www.nature.com Antiviral immunity via telomerase-like reverse transcription in bacteria Nature - Antiviral immunity via telomerase-like reverse transcription in bacteria Excited to share that our work on DRT10 is now out in @Nature!
nature.com/articles/s4158…
1/2 Here we report the activity of Arc, a 50-aa DNA-binding protein encoded within IS605-family transposons. biorxiv.org/content/10.648…
1/13 — New pre-print from the Sternberg Lab in collaboration with Leifu Chang's Lab! TnpB nucleases have repeatedly given rise to TldRs, nuclease-dead RNA-guided transcription factors. Here we define the biological role of a TldR clade in its native host.
biorxiv.org/content/10.648…
biorxiv.org/content/10.648…
Just published! IStrons are a unique class of transposable elements that pack three distinct functions in one sequence. Here, we used pooled library mutagenesis and high-throughput sequencing to systematically map the sequence and structural features that govern these functions.