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Izabela Sumara

@SumaraLab

PI @IGBMC, research director DR1 @CNRS. Cell cycle, NPC, ubiquitin, disease. Alumna @JagiellonskiUni @IMPvienna @ETH_en. Hobby cook and occasional runner.
Strasbourg, France igbmc.fr/igbmc/missions… Joined December 2018
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Izabela Sumara @SumaraLab
I’m very happy to share a press release about our recent publication on how annulate lamellae build new nuclear pores. 🔬🥳

Grateful to @CNRS for highlighting our work and helping share these findings! 🙏✨
CNRS Biologie @CNRSbiologie Sep 3
#ResultatScientifique🔎| Comment les cellules construisent-elles les milliers de pores qui assurent les échanges entre le noyau et le cytoplasme ? Dans @NatureComms des scientifiques révèlent le rôle insoupçonné des lamelles annelées

✍️ Izabela Sumara

buff.ly/qLaqasN
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Izabela Sumara @SumaraLab
Very proud of our new publication in EMBO Molecular Medicine 🥳, where we describe an antimitotic that selectively inhibits tumor growth without affecting normal tissues.

link.springer.com/article/10.103…
link.springer.com Pharmacological inhibition of UBASH3B induces mitotic arrest and selectively reduces tumor growth EMBO Molecular Medicine - Cancer cells tolerate mitotic errors to sustain proliferation, yet the molecular dependencies enabling this tolerance remain poorly understood and largely unexploited...
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Izabela Sumara @SumaraLab
Our new study is out! 🎉🚀
Annulate lamellae aren’t just static reservoirs, they dynamically supply pre-assembled nuclear pores to the nucleus (~1/3 of new NPCs) in normal somatic cells. A new pathway for nuclear pore assembly supporting nuclear expansion. pubmed.ncbi.nlm.nih.gov/41882018/
pubmed.ncbi.nlm.nih.gov RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion - PubMed Nuclear pore complexes (NPCs) enable nucleocytoplasmic transport. While NPCs primarily localize to the nuclear envelope (NE), they also appear in cytoplasmic endoplasmic reticulum (ER) membranes...