Bryson Lab

@TheBrysonLab

Engineering innate immunity // Host-pathogen interactions // Systems Biology // Tuberculosis @MIT @MITDeptOfBE

Boston, MA brysonlab.mit.edu Joined September 2017

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Latest posts 5

Antigen discovery and TB vax friends 🧵

We set out to find more Mtb peptides presented on MHC-I. We had a strong biological prior, a high-throughput binding screen, and a very sensitive targeted MS assay.

Of 286 candidates, we detected 2.

biorxiv.org/content/10.648…

www.biorxiv.org Multiple bottlenecks constrain presentation of Mycobacterium tuberculosis antigens on MHC class I CD8+ T cell recognition of pathogen-derived peptides presented on major histocompatibility complex class I (MHC-I) contributes to protective immunity against intracellular pathogens like Mycobacter...

Bryson Lab @TheBrysonLab May 22

Anyone in my science network have experience with producing soluble TCRs? Better yet affinity maturation of TCRs?

Bryson Lab @TheBrysonLab Jan 28

Anyone in the de novo minibinder design space using their binders as flow cytometry staining reagents? Would love to compare notes if so!

Bryson Lab @TheBrysonLab Nov 20, 2025

Happy to share our newest preprint on antigen presentation of Mtb-derived peptides on MHC-I: biorxiv.org/cgi/content/sh…

This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070

Bryson Lab @TheBrysonLab Nov 17, 2025

Excited to share our lab's newest preprint (strap in if you're excited about metabolism, species differences, or Mtb gene expression): biorxiv.org/content/10.110…

www.biorxiv.org Systems analysis reveals alternate metabolic states adopted by Mycobacterium tuberculosis across... Mycobacterium tuberculosis (Mtb) persists within macrophages, yet how different host species shape bacterial state remains poorly understood. Here, we directly compared the intracellular transcript...