The Clevers Lab

Using snake airway organoids, we modelled reptile virus infection in vitro. With a new Python Regius reference genome, we show that our organoids contain multiple cell types, could mount an immune response and respond to antivirals.

Paper: nature.com/articles/s4146…

1/4 Gut renewal is not passive “crowd control.” Instead of being pushed out by crowding or dying from apoptosis, cells compete in a mechanical tug-of-war. Weaker cells are eliminated—reframing intestinal homeostasis as a force-regulated process. science.org/doi/10.1126/sc…

Do you want to learn how to make mouse thymus organoids?

Our lab recently published a STAR Protocol on generating thymic epithelial organoids from adult mouse thymus tissue.

Read it here: doi.org/10.1016/j.xpro…

#Thymus #Organoids #STARProtocol #TEC

Our PhD student Sam presented our work on thymus organoids at this year’s Global Thymus Network meeting, ThymUS 2025.

#ThymUS2025 #Organoids #Thymus

Check out new @TheScientistLLC article highlighting our postdoc @AmandaARolf ’s work on a novel pancreatic organoid model that includes all three key cell types, offering new insights into pancreatic development: the-scientist.com/a-novel-three-…