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Miloš Tišma

@TismaMilos

Biology is life 🍃
Postdoc at Harvard Medical School @harvardmed| Loparo +TJ Ha labs |
PhD at TU Delft @tudelft | Cees Dekker lab |
🇺🇸 via 🇳🇱,🇩🇪,🇷🇸 Joined December 2019
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Miloš Tišma @TismaMilos
I'm happy to share the first paper from my postdoc work:
biorxiv.org/content/10.648…

How does RecA find one homologous sequence -and what turns that encounter into a repair-competent one?

We find that DNA topology is the gatekeeper!

With @anjbadri / @JoeLoparo / TJ Ha 🙏

1/10
www.biorxiv.org Chromosome topology gates productive RecA homology search In homologous recombination, DNA repair depends on recombinase filaments finding homologous templates on chromosomes whose topology is continually remodeled by replication and transcription. How...
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Miloš Tišma @TismaMilos
Probably the best thing I've seen this year! Absolutely beautiful animation of DNA repair machinery.
Divinely Designed Verified account @DivinelyDesined Jan 28
Incredible.

This is the DNA Repair System. Look how many parts work together to make the system function.

Without DNA Repair, mutations in DNA would completely destroy its functionality very quickly - it would degrade rapidly into non-functional junk. Which means, the DNA Repair System would have to have been around since the very beginning of Life; DNA and the Repair Systems would have to arise together, at the same time, or DNA could not survive - and neither could Life.

But how complex is the DNA Repair System?

It requires 6-7 major systems, working in coordination together. Combined, those systems contain a total of about 130-200+ total unique proteins that make up the systems to do the job.

Two things make this system most likely designed:

1. DNA cannot survive without DNA Repair. The entire system must be in place at the very start of Life, or Life never starts. But creating the systems requires the information in DNA - they both must arise together, simultaneously.

2. The specified, irreducible complexity of the system. DNA Repair requires a minimal amount of specifically engineered protein systems to function. Just look at how many separate systems are involved in that process!

How can anyone see something like this and believe it arose by an accident of natural processes?

Life is so clearly intelligently Created.
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