@TomZhendong
(1/n) Excited to share our new preprint! We uncover that RNA actively promotes nucleation and function of pathogenic condensates, amplifying locus-specific oncogenic transcription and promoting tumorigenesis. #epigenetics #condensates #cancer #RNA biorxiv.org/content/10.110…View quoted post on X
Excited to announce a new paper in @CD_AACR with @junwei_s, @TomZhendong, @DaniyanMd and led by @PuZhang09980432. We perform screens of GAPs and GEFs in AML and discover a hematopoietic-specific GAP (ARHGAP45) required in AML:
aacrjournals.org/cancerdiscover…View quoted post on X
congratulations to @kristaa122995 for becoming a Ph.D. candidate! so proud of you and can't wait to see the great things you will achieve next! @PennCBP @CAMBUpenn @Penn_CBIO #ProudPIView quoted post on X
1/Excited to share my first author publication where we create split-engineered base editors (seBEs). Here, we place base editors under the control of a small-molecule to regulate the timing of genome editing and decrease off-target effects. To achieve it: nature.com/articles/s4158…View quoted post on X
We are thrilled to share our latest publication at @MolecularCell about a multiple PTM reader ZMYND8 in regulating an AML-specific TF circuit! authors.elsevier.com/c/1dX3Z3vVUPGK…View quoted post on X
