Tyler Pitre, MD PhD🇨🇦

@TylerSC10

🇨🇦Canadian I Respirologist🫁| PH-ILD Doctor @uhn| Alumnus @UNB @WesternU @mcmasterU @uniofeastanglia.

Founder of coreSR.ai.

Toronto coreSR.ai Joined September 2019

787 Following 579 Followers 1.2K Posts

Latest posts 5

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Tyler Pitre, MD PhD🇨🇦 @TylerSC10 Sep 8

Our CARE-PF analysis is out in Respirology.

n=4236 fibrotic ILD. Transplant-free survival 91%/72%/57% at 1/3/5 yr (IPF 39%; CTD-ILD 70% at 5 yr).

@UofT @UHN @UofT_DoM
doi.org/10.1002/resp.7…

Tyler Pitre, MD PhD🇨🇦 @TylerSC10 Oct 7

Is JEV a new architecture? It might just be a smallish LLM with a muzzle...#jev #llm #ai

youtube.com/watch?v=UdHV21…

www.youtube.com I Interrogated the AI That Can't Speak: Truth about JEV Jev, from TypeSafe AI, is a model that cannot write a word. The com...

Tyler Pitre, MD PhD🇨🇦 @TylerSC10 Oct 1

Pulse-dose steroids for acute exacerbation of IPF: do they actually save lives? 🧵

SAFER just published in AJRCCM, a multicenter randomized trial testing this head-on. Short answer below. 1/5

#IPF #ILD #PulmTwitter

Tyler Pitre, MD PhD🇨🇦 @TylerSC10 Sep 30

Not all ILA progresses. Can CT AI flag who will?
COPDGene+AGES: MIL-UIP. Score>0.5 → ~13–14%/yr fibrosis↑; death HR~1.6 both cohorts.

Takeaway: automated UIP-like CT may risk-stratify ILA.
Caveat: observational; needs validation.

#ILD #IPF #PulmTwitter
doi.org/10.1093/ajrccm…

academic.oup.com Deep learning classification of radiologic pattern is associated with progression of interstitial... AbstractRationale. Interstitial lung abnormalities (ILA) are common, but not all progress, highlighting the need for objective computed tomography (CT)-bas

Tyler Pitre, MD PhD🇨🇦 @TylerSC10 Sep 29

Still hunting IPF biomarkers—MMP-1/9 data.

n=128 IPF (74 stable/54 AE)+26 ctrl. MMP-9 ↑ vs ctrl. Stable IPF: +1 µg/L MMP-1 → +20% death HR (CI 2–42%; adj incl FVC).

Promising stratification; single-center until replicated.
doi.org/10.1177/175346…
#IPF #ILD #PulmTwitter

journals.sagepub.com The diagnostic and prognostic role of MMP-1 and MMP-9 plasma concentrations in idiopathic pulmonary... Background Idiopathic pulmonary fibrosis (IPF) represents a chronic and irreversible progressive disease, while acute exacerbation of idiopathic pulmonary fibro...