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Victoria Cornelius

@VR_Cornelius

Medical Statistics and Trial Methodology. Director of Imperial Clinical Trials Unit.
London, England imperial.ac.uk/people/v.corne… Joined July 2015
1.1K Following 2K Followers 2.8K Posts

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Victoria Cornelius @VR_Cornelius
This trial result from #GASTROSAM at #CCR25 reviewed there is so much more here for interpretation than headline journal conclusions.
Large effect of the trial as an intervention on outcomes but important new understanding of safety (albeit under ideal conditions).
NEJM Verified account @NEJM Jun 13, 2025
Presented at #CCR25:

A trial involving children with severe acute malnutrition and gastroenteritis showed no evidence of a difference in mortality at 96 hours between oral and intravenous rehydration strategies. Full GASTROSAM trial results: nej.md/3TjfSP7

@CritCareReviews
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Victoria Cornelius @VR_Cornelius
#ANH at #CCR25
Does acute normovolemic hemodilution for elective cardiac surgery reduce transfusion rate?
No evidence from this large double blind pragmatic trial. Methods wise the dichotomisation of outcome >=1 unit would lose information and I wonder about site heterogeneity
NEJM Verified account @NEJM Jun 12, 2025
Presented at #CCR25:

In the ANH phase 3 trial involving adult patients undergoing elective cardiac surgery, acute normovolemic hemodilution did not reduce the number of patients receiving allogeneic red-cell transfusion. Full trial results: nej.md/3FxdMrW

@CritCareReviews
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