Vamsi Mootha

@VamsiMootha

physician-scientist studying mitochondria, oxygen, bioenergetics Tweets = my own

Cambridge, MA mootha.med.harvard.edu/index.html Joined July 2016

381 Following 6.1K Followers 395 Posts

Latest posts 5

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Vamsi Mootha @VamsiMootha Oct 1

Today, the MitoCarta Tree of Life Consortium (MitoTOL) is releasing high-accuracy mitochondrial proteomes across diverse eukaryotes to empower studies of physiology, evolution, and disease:

cell.com/consortium/mit…

All data can be accessed at:

mitocarta.org

Vamsi Mootha @VamsiMootha Oct 14

Introducing our next-gen “hypoxia in a pill” - we upgrade the combo by replacing GBT440 w/ 2nd-gen Hb affinity enhancer GBT601, and continue to pair with HIF-2α inhibitor PT2399. Highly effective in advanced Parkinson’s dz and Leigh syndrome mouse models
tinyurl.com/35x36ayx

Vamsi Mootha @VamsiMootha Oct 8

So proud to see @rahulg603 receiving this recognition! His work on mitonuclear genetic variation across nearly 1M humans is revealing deep insights into disease and aging. The future of biomedicine is bright! @broadinstitute @MassGeneralNews

Rahul Gupta @rahulg603 Oct 7

So excited to be selected one of STAT’s 2026 Wunderkinds. Huge thanks to my PhD advisors @VamsiMootha & Ben Neale + all my incredible mentors & colleagues. It's a huge honor to be in this inspiring cohort of scholars! @statnews #STATWunderkinds

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Vamsi Mootha @VamsiMootha Sep 16

Our MGH Dept of Molecular Biology is hiring. It’s an exceptional *basic* science dept with a longstanding track record for curiosity driven science, great colleagues / infrastructure and generous support.

Assistant Professor nature.com/naturecareers/…

www.nature.com Assistant Professor - Boston, Massachusetts Assistant Professor, Depts. of Molecular Biology (Massachusetts General Hospital) and Genetics (Harvard Medical School). Tenure track.

Vamsi Mootha @VamsiMootha Sep 10

Our preprint is now published: In collab. w/ Ruma Banerjee we show how the B12 chaperone MMADHC spends its life in two cellular 'zip codes' dictated by the mitochondrial PMF (similar to PINK1). Co-led by @Sneha_Rath_, Zhu Li. doi.org/10.1073/pnas.2…

www.pnas.org Mitochondrial depolarization stabilizes the vitamin B12 chaperone MMADHC in the cytosol to increase... Of the ~1,100 mitochondrial proteins, only a handful like PINK1 and ATFS-1 are known to stabilize and relocalize upon collapse of the proton motive...

Vamsi Mootha @VamsiMootha Jan 2

Excited to share new work in collaboration w/ Ruma Banerjee’s group. Following mitochondrial depolarization, the vitamin B12 chaperone MMADHC is stabilized and boosts B12-dependent MTR activity in the cytosol. Regulation is reminiscent of PINK1, ATFS1.
biorxiv.org/content/10.648…
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