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William J. Greenleaf

@WJGreenleaf

Professor, Stanford University, Department of Genetics. Exploring the physical genome
Stanford U, Stanford CA greenleaf.stanford.edu/index.html Joined July 2011
120 Following 11K Followers 162 Posts

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William J. Greenleaf @WJGreenleaf
Our new preprint on remote memory and chromatin metaplasticity, in collaboration with the Schnitzer lab, is now live on BioRxiv! Congrats to @Yuxi_Ke!
biorxiv.org/content/10.648…
x.com/yuxi_ke/status…
www.biorxiv.org Memory encoding reprograms neuronal transcriptional responses via durable chromatin remodeling The mammalian brain’s long-term memory circuits integrate information from prior and new experiences. The medial prefrontal cortex (mPFC) has a crucial role in this process and can reliably store...
Yuxi Ke Verified account @Yuxi_Ke Aug 11
Chromatin has long been proposed to "store" memory related information; but what kind of information, contents or rules does it hold?

Check out our new preprint: biorxiv.org/content/10.648… 1/13
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1 replies 20 reposts 127 likes 15K views View on X
William J. Greenleaf @WJGreenleaf
Our new preprint on remote memory and chromatin metaplasticity, in collaboration with the Schnitzer lab, is now live on BioRxiv! Congrats to @Yuxi_Ke! biorxiv.org/content/10.648…
www.biorxiv.org Memory encoding reprograms neuronal transcriptional responses via durable chromatin remodeling The mammalian brain’s long-term memory circuits integrate information from prior and new experiences. The medial prefrontal cortex (mPFC) has a crucial role in this process and can reliably store...
0 replies 13 reposts 71 likes 8K views View on X
William J. Greenleaf @WJGreenleaf
Our preprint describing the adaptation of the PIP-seq platform for scalable, inexpensive multiomics is now live on BioRxiv! Congrats to Zhifei Luo (@LuoZhifei)! biorxiv.org/content/10.648…
www.biorxiv.org A Simple, Cost-Effective, High-Throughput Method for Measuring Chromatin Accessibility and Gene... We describe microfluidic-free, droplet-based methods for single-nucleus epigenomic measurements: Particle-templated Instant Partition single-nucleus assay for transposase-accessible chromatin using...
1 replies 26 reposts 144 likes 12K views View on X
William J. Greenleaf @WJGreenleaf
Our Human Multiomic Development Atlas paper is out in Nature today! A heart-felt "thank you" to all co-authors for their tireless work on this complex yet exciting project! Congrats all! nature.com/articles/s4158…
www.nature.com Multiomics and deep learning dissect regulatory syntax in human development Nature - The Human Development Multiomic Atlas catalogues single-cell accessibility and gene expression data from human fetal cells across 12 organs, enabling the inference of syntactic rules for...