Walczak Lab

@Walczak_Lab

Studying the functional interplay between cell death, inflammation and (auto-)immunity
#inflammation #celldeath #immunity #cancer
@uclcancer @BCCologne @CECAD_

Cologne, Germany Joined March 2024

402 Following 215 Followers 29 Posts

Latest posts 5

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Walczak Lab @Walczak_Lab Mar 6

Excited to share our new work uncovering a previously unknown mechanism identifying ANKIB1 as the E3 ligase that writes a critical new letter of the ubiquitin code central for immune signalling: K11-linked ubiquitin nature.com/articles/s4155…

www.nature.com Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS–STING and Toll-like... Nature Cell Biology - Betrancourt, Cinko et al. identify ANKIB1-mediated K11 ubiquitination and OPTN recruitment as a shared mechanism for driving immune signalling by cGAS, TLR3 and TLR4, with...

Walczak Lab @Walczak_Lab Jun 25, 2025

I am honoured to give tonight's Keynote Lecture at the Alexander von Humboldt Foundation Annual Meeting @ 18:00 CET (25th June 2025)

Follow the live stream at lnkd.in/dBQnjJpM

Walczak Lab @Walczak_Lab Nov 14, 2024

Promising new treatment approach for severe COVID-19! Clinical trial with Fas ligand blocker shows faster recovery & reduced mortality. Approach targets immune overreaction, potentially effective against future viruses too. #COVID19 #Science #PublicHealth
t.ly/6kalU

Walczak Lab @Walczak_Lab Sep 4, 2024

Particularly happy my former group members, @PeltzerNieves and Diego de Miguel, both now independent Principal Investigators, signed as co-senior authors on this study. My congrats also to first author Yu-Guang Chen for his outstanding work! #Uni_Stuttgart #IISAragon #NDMC

Walczak Lab @Walczak_Lab Sep 2, 2024

Very excited about our recent publication in Cell Death & Differentiation @SpringerNature
Many thanks to all contributors and the great collaboration! #ucl #UniCologne #NDMC #UniStuttgart #IISAragón
nature.com/articles/s4141…
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Walczak Lab @Walczak_Lab Sep 2, 2024

Very excited about our recent publication in Cell Death & Differentiation @SpringerNature
Many thanks to all contributors and the great collaboration! #ucl #UniCologne #NDMC #UniStuttgart #IISAragón
nature.com/articles/s4141…

www.nature.com LUBAC enables tumor-promoting LTβ receptor signaling by activating canonical NF-κB Cell Death & Differentiation - LUBAC enables tumor-promoting LTβ receptor signaling by activating canonical NF-κB