Xiao Wang

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@WangXiaoLab

Associate Professor at MIT Chemistry and Core Member at Broad Institute of MIT and Harvard

Boston wangxiaolab.org Joined June 2018

512 Following 6K Followers 140 Posts

Latest posts 5

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Xiao Wang @WangXiaoLab Sep 23, 2024

Chapter 2 of branched RNA: chemically modified branched cap for multi-capped mRNA and capped circular RNA (QRNA)--the cellular translation machinery is surprisingly tolerant of unnatural structures! Beyond enhanced performance, the mechanism is intriguing: rdcu.be/dUQKX

Hongyu Chen @HongyuChenChem Sep 23, 2024

Synthesizing RNA can be as fun as LEGO puzzles! This work is co-led by my incredible colleagues @LDangliang and @AbhiAditham . Huge thanks to my supervisor @WangXiaoLab for such amazing ideas. We are also grateful for the editor, reviewers, and all collaborators along the way.

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Xiao Wang @WangXiaoLab Sep 23, 2024

Happy to share CAST as the "BLAST" tool for spatial omics, searching and aligning similar patterns across datasets while revealing their differences with prototype demo of querying new data against reference spatial atlas and comparative spatial studies👇rdcu.be/dULBj

Shuchen Luo @nemo08061 Sep 20, 2024

CAST enables physical alignment of spatial omics data across replicates, techs, modalities at single-cell resolution. Such accurate alignment enables spatial atlas searching, unbiased DEG identification, and reconstruction of spatial multi-omics. DM for questions and collabs!

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Xiao Wang @WangXiaoLab Mar 22, 2024

Why can RNA only be linear or circular? It can be branched! We made multi-tailed mRNA, and we had fun! Here is our story led by brilliant graduate student @HongyuChenChem: rdcu.be/dB7ck and his cartoon illustration👇@ChemistryMIT @broadinstitute

Hongyu Chen @HongyuChenChem Mar 22, 2024

Thrilled to see our work on chemically and topologically engineered mRNA online! Using a chemo-enzymatic approach, we introduced multiple end-modified polyA tails on a single mRNA to boost its stability and translatability overtime. nature.com/articles/s4158…

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Xiao Wang @WangXiaoLab Sep 28, 2023

Thanks so much! Our molecular tissue region analysis was greatly inspired by your earlier work and the concept of unsupervised (non-expert, data-driven), molecular redefinition of neuroanatomy

Xiao Wang @WangXiaoLab Sep 28, 2023

Huge congrats to Hailing and the whole team, and thanks so much for the suggestions and help from the editor, reviewers, and colleagues through the long journey! Spatial atlas of the mouse central nervous system at molecular resolution: rdcu.be/dnaYu

Hailing Shi @HailingShi Sep 27, 2023

Thrilled to see our work finally online! We utilized in situ spatial transcriptomic method STARmap PLUS to map 1.09 million cells in the adult mouse central nervous system at molecular resolution and identified previously unknown tissue architectures.
nature.com/articles/s4158…
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