Marius Wernig

@WernigLab

We in the Wernig lab are excited about coding neurons and glia by reprogramming and develop human cell models and next generation cell therapies for the brain

Stanford, CA werniglab.org Joined March 2022

63 Following 1.1K Followers 28 Posts

Latest posts 5

Marius Wernig @WernigLab Jul 16, 2024

Check out our next-generation stem cell (iPSCs)- & CRISPR-based approach to treat dystrophic epidermolysis bullosa. Hot off the press: nature.com/articles/s4146…

#cellandgenetherapy #regenerativemedicine #genomeengineering #DEBRA #CIRM

www.nature.com A scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis... Nature Communications - Dystrophic Epidermolysis Bullosa is an uncurable monogenetic skin disease. Here, Neumayer et al. develop a cGMP-compatible CRISPR- and iPS cell-based approach that produces...

Marius Wernig @WernigLab Mar 22, 2024

A reactive myeloid state is neuroprotective in chronic neuroinflammation that can be enhanced by microglial replacement! Congrats to @marius_mader and all co-outhors in collaboration with @wysscoray and Larry Steinman. thanks @NatureNeuro! nature.com/articles/s4159…

Marius Wernig @WernigLab Mar 22, 2024

Great achievement!

Alice Ting Verified account @aliceyting Mar 22, 2024

LYTACs pioneered by @CarolynBertozzi opened the door to degradation of cell surface and extracellular proteins through lysosomal targeting. Here, we introduce genetically-encoded LYTACs, or GELYTACs, which are (1) easier to produce by recombinant expression (LYTACs, antibody conjugates to glycopeptides, are harder to make), (2) amenable to engineering via directed evolution, and (3) possible to secrete from therapeutic cells such as T-cells.

We demonstrate degradation of various soluble targets, including TGFb, IL6R ectodomain, and mCherry with GELYTACs optimized via yeast display directed evolution, added either as recombinant protein or secreted from living T-cells.

Congratulations to lead author @Jony_theChemist, our wonderful collaborators Sean Yamada-Hunter, @LouaiLabanieh and @molecular_elena from the @mackalllab, and great teaming up again with the formidable @CarolynBertozzi.

pnas.org/doi/10.1073/pn…
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Marius Wernig @WernigLab Mar 6, 2024

Excited to share that Cheen’s paper got published in PNAS today! We found that Emx1+Ngn2 produces more homogeneous excitatory forebrain neurons than Ngn2 alone. pnas.org/doi/10.1073/pn…. Thanks @PNASNews and all co-authors!

Marius Wernig @WernigLab Sep 26, 2023

All Molecular/Cellular Neuroscientists interested, please apply!

Stanford Neurosurgery @StanfordNsurg Sep 25, 2023

Stanford Neurosurgery seeks a basic or translational neuroscientist with a proven track record in molecular and cellular neurobiology to join the Department as Assistant, Associate or Full Professor. @StanfordBrain #neurojobs #neurotwitter

Apply here: bit.ly/3Zoz6Fj

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