Our new paper by postdoc Man Wu @manwu381774343 "The centrosomal hub unifies regulatory factors of NLRP3 inflammasome activation" provides a simple, unified insight on this complicated beast of NLRP3 inflammasome! pnas.org/doi/10.1073/pn…
Prof. Hao Wu
@WuLabHarvard
Asa and Patricia Springer Professor of Structural Biology @ Harvard Medical School and Boston Children’s Hospital. #immunology #structure_biology
164 Following 6.1K Followers 262 Posts
Latest posts 5
Ever wondered why only inflammasomes that use ASC, but not those that do not use ASC, can mature IL-1β? ASC helps to recruit pro-IL-1β to ASC for caspase-1 processing! See: "Inflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation" pnas.org/doi/10.1073/pn…
www.pnas.org Inflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation | PNAS Inflammasome activation triggers caspase-1-dependent maturation of pro-interleukin-1β (pro-IL-1β) in an apoptosis-associated speck-like protein con... I’m so excited and proud that my student Jennifer Wang @Jennnwww has received so many kudos for her Master’s thesis talk in Immunology @harvardmed! @ShivPillai4 Congratulations, Jennifer! @Luochen_Liu1 @jf033 @ZhoupingH @AhmetBugraTufa2 @PiXiong_3 @L_Heals
Excited to share our paper on the NLRP3 inflammasome condensate at the MTOC by "precise!" cryo-electron tomography (cryo-ET), in collaboration with Jue (phyllis) Wang@Phyllis23382012in the labs of Grant Jensen (BYU) and Pete Dahlberg (Stanford)! science.org/doi/10.1126/sc…
www.science.org Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing... Cryo-ET reveals that the NLRP3 inflammasome in human macrophages forms a condensate that disrupts the MTOC. Excited to share an amazing video on the NLRP3 inflammasome pathway generated by talented Ann from the Iwasa lab @janetiwasa @Ann_HuiLiu. It shows the real cryo-EM structures of the pathway from #NLRP3, #ASC, #caspase-1, #GSDMD, #IL-1b, to #NINJ1. #cryoem @LeXiao17 Enjoy
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