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Yale Department of Genetics

@YaleGenetics

Official Twitter home of the Yale University Department of Genetics. Sharing the latest advances in genetics, news and upcoming events.
New Haven, CT Joined February 2019
2K Following 3.8K Followers 4.5K Posts

Latest posts 5

Yale Department of Genetics @YaleGenetics
A study of 1 million diverse genomes identified mutations in FNIP1 linked to more muscle, less belly fat & lower blood sugar. Carriers had a 60% reduced risk of cardiometabolic disease, pointing to a possible drug target for diabetes + heart disease
nature.com/articles/d4158…
www.nature.com More muscle, less belly fat: mutations to a gene are linked to wide-ranging benefits Nature - Analysis of one million diverse genomes yields mutations associated with lower risk of diabetes, heart disease and other ‘cardiometabolic’ conditions.
Yale Department of Genetics @YaleGenetics
Human pluripotent stem cells often develop differentiation biases in the lab, limiting disease modeling. A new study traces this to epigenetic drift and offers a chemical approach to restore their full differentiation potential.
nature.com/articles/s4158…
www.nature.com Restoring pluripotency to pluripotent stem cells Nature Biotechnology - Human pluripotent cell lines that cannot generate cortical organoids are rescued by an epigenetic reboot.
Yale Department of Genetics @YaleGenetics
CRISPR is getting an upgrade. Instead of cutting DNA, a new wave of epigenetic editors modify the chemical markers attached to it, switching genes on/off without altering the genetic code itself. Safer, reversible, & showing promise in early trials
nature.com/articles/d4158…
www.nature.com CRISPR’s next act: the companies editing the epigenome to treat disease Nature - A handful of start-up firms are testing therapies that target specific epigenetic markers to treat everything from high cholesterol to a rare muscular disorder.
4 replies 29 reposts 108 likes 5.1K views View on X
Yale Department of Genetics @YaleGenetics
🐙 Octopuses are strange down to their molecules. A mutation in their ribosomal RNA gene, found in no other organism on Earth, makes their protein-building machinery exceptionally accurate, resulting in fewer errors and less toxic protein buildup.
science.org/content/articl…
www.science.org A molecular quirk unique to octopuses makes them better at building proteins Certain shallow-water species carry a mutation that reduces translation errors and prevents toxic protein buildup