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KerenYizhakLab

@YizhakLab

Computational Cancer Genomics Lab - Turn Cancer Data into Knowledge
Joined March 2021
156 Following 128 Followers 43 Posts

Latest posts 5

KerenYizhakLab @YizhakLab
📢 Excited to share our new paper in @CellGenomics!
We analyzed matched #scRNAseq and #scTCRseq from 767K T cells to uncover clonal programs that predict response to immune checkpoint inhibitors.
👉 cell.com/cell-genomics/…
#CancerImmunotherapy
www.cell.com Single-cell meta-analysis of T cells reveals clonal dynamics of response to checkpoint immunotherapy Shorer et al. perform paired scRNA/TCR-seq meta-analysis of 767,606 T cells obtained from patients with cancer treated with checkpoint immunotherapy across multiple cancer types. Their findings...
KerenYizhakLab @YizhakLab
🚨 New preprint alert! We performed scRNA-seq & scTCR meta-analysis on cancer patients treated with ICIs, revealing key T cell signatures linked to therapeutic response, with insights into clonal replacement vs reinvigoration! #scRNAseq #Immunotherapy

biorxiv.org/content/10.110…
www.biorxiv.org Single-cell meta-analysis of T cells reveals clonal dynamics of response to checkpoint immunotherapy Despite the crucial role of T cell clones in the anti-tumor activity, their characterization and association with clinical outcome following immune checkpoint inhibitors (ICI) is lacking. Here we...
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KerenYizhakLab @YizhakLab
In these darkest days our country have ever known, we somehow manage to do science. Our new paper shows how #metabolism of immune cells predicts patients response to ICI. Ofir finished this paper while in reserve duty helping to bring our people back home
cell.com/iscience/fullt…
www.cell.com Metabolic predictors of response to immune checkpoint blockade therapy Human metabolism; Immunology; Cancer