Ziad Mallat (@ZMallat)

@EricTopol In a LinkedIn post, I provide some additional mechanistic explanation for the absence of CV benefit with pelacarsen in patients with advanced atherosclerosis: lnkd.in/p/eF_r5xZK

www.linkedin.com Where Next for Lp(a)? | Ziad Mallat The HORIZON results are now published in NEJM Group (Cho L et al.). In an extended analysis published in NEJM Evidence (Nissen SE et al.), the authors report that « When evaluating participants with...

Eric Topol Verified account @EricTopol 2d

Today #AHA26 and @NEJM the 2 big trials of secondary prevention of heart disease with an IL-6 antibody and Lp(a) antisense oligonucleotide. No beneficial effect, overall and across all subgroups
nejm.org/doi/full/10.10…
nejm.org/doi/full/10.10…

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Ziad Mallat @ZMallat 3d

The difference between an illiterate @GadSaad and a literate @MouinRabbani. « The blind and the seeing are not alike. Nor are darkness and light »!

Mouin Rabbani Verified account @MouinRabbani 3d

Elon Musk's pet demagogue, the serial fabricator and bigoted dummy Gad Saad, is once again full of shit.

Importantly, Saad knows he is full of shit, yet insists on repeatedly doubling down on his numerous, documented fabricated falsehoods (see link in comments).

In my view Saad's insistence on obsessively repeating what he knows to be fabricated falsehoods can only be interpreted as incitement to anti-Muslim violence and terror.

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Ziad Mallat @ZMallat Oct 2

@MariosGeorgakis but in the jama paper you cite, Lp(a) change of 100mg/dL is as protective as 38.67 mg/dL change of LDL-C. Since 100mg/dL Lp(a) corresponds to approx 17mg/dL of Lp(a)-C (see @Lpa_Doc ), Lp(a)-C (over a lifetime) appears to be more not less atherogenic than LDL-C.

Marios Georgakis Verified account @MariosGeorgakis Oct 2

🔗links to the sources of the figures:
nature.com/articles/s4156…
link.springer.com/chapter/10.100…
jamanetwork.com/journals/jamac…
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Ziad Mallat @ZMallat Sep 19

Un salopard 👇

Damien Rieu Verified account @DamienRieu Sep 19

Je ne le souhaite évidemment pas mais je suis certain que si la France était demain en conflit militaire avec conscription, des centaines de milliers de Français bi-nationaux qui ne se sentent finalement pas très Français feraient leur valise illico. Ils le disent en privé d’ailleurs.
Ça aurait au moins le mérite de faire le tri.
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Ziad Mallat @ZMallat Sep 5

Interesting analysis. The issue with FAI is that we still need to have solid data that it can be altered by treatment (and that such a reduction links to reduction in CV events). There are some data but not solid enough in my opinion.

Eric Topol Verified account @EricTopol Sep 5

Why did 2 large, pivotal clinical trials [vs interleukin-6 and Lp(a)] fail to lower heart attacks, strokes and cardiovascular deaths?
In the new Ground Truths (link in profile)

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Ziad Mallat

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