Shaoshi Zhang

@ZShaoshi

neuroscience, computational psychiatry | Computational Brain Imaging Group | Center for Brain Circuit Therapeutics | Huge fan of Edward Hopper

Singapore Joined May 2020

176 Following 219 Followers 188 Posts

Latest posts 5

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Shaoshi Zhang @ZShaoshi Oct 6

1/11 Our new paper is out in Alzheimer’s & Dementia! 🚨
Does cortical excitation–inhibition (E/I) imbalance link amyloid pathophysiology to memory? We tested this in non-demented older adults (cognitively normal + MCI) across two independent cohorts. 🧵👇
doi.org/10.1002/alz.71…

Shaoshi Zhang @ZShaoshi May 21

For years, we've known that running a standard t-test on cross-validation folds violates sample independence. We wanted to see how widespread this issue actually is.

The result? 97% of the studies used an invalid statistical test. 🧵👇

Thomas Yeo @bttyeo May 21

In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests.

Here's our new preprint doi.org/10.64898/2026.… led by @tianchuzeng @kkli20111 @ZShaoshi @ten_photos 1/N

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Shaoshi Zhang @ZShaoshi Mar 3

Thank you @shansiddiqi and @foxmdphd for the kind invitation to share one of the projects I’m most proud of. This work would not have been possible without my amazing co–first authors @Leon_Oo1 and @csabaorban ! Super grateful for their tremendous contributions!

Michael Fox @foxmdphd Mar 3

Welcome @ZShaoshi to @Brain_Circuits @MGBResearchNews @BWHNeurology Very excited to work with you!

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Shaoshi Zhang @ZShaoshi Jul 17, 2025

Thrilled to share our latest work just published in @Nature where we looked into the optimal fMRI scan time for brain-wide association studies (BWAS)! Full thread below 👇

Thomas Yeo @bttyeo Jul 17, 2025

1/11 Excited to share our @Naturestudy led by @Leon_Oo1 @csabaorban @ZShaoshi

doi.org/10.1038/s41586…

It is well-known that AI performance scales with logarithm of sample size (Kaplan, McCandlish 2020), but in many domains, sample size can be # participants or # measurements...

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Shaoshi Zhang @ZShaoshi Apr 11, 2025

Check out our latest preprint led by the amazing @tianchuzeng and @t___fang where we speed up the tedious parameter optimization process for biophysical modelling🔥👇

Thomas Yeo @bttyeo Apr 11, 2025

While the world burns, we cook up a new preprint! doi.org/10.1101/2025.0…

Biophysical modeling is a key tool to derive mechanistic insights into the brain. These models are governed by biologically meaningful parameters (unlike deep neural nets), but the dirty secret ... 1/N

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