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Zach Wickens

@ZachWickens

Associate professor at UW-Madison. Privileged to work with the @WickensGroup. Views my own.
wickens.chem.wisc.edu Joined January 2017
441 Following 3K Followers 1.2K Posts

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Zach Wickens @ZachWickens
As part of our ongoing collaboration with @Charles_chem at Merck, we found a new way to promote alkene carboxy-alkylation that exploits the unique chemoselectivity profile of CO2•- accessed from formate! Check it out: pubs.acs.org/doi/full/10.10…

Congrats to all the authors!!
pubs.acs.org Alkene Carboxy-Alkylation via CO2•– Abstract. Herein, we introduce a new platform for alkene carboxy-alkylation. This reaction is designed around CO2•– addition to alkenes followed by radical
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Zach Wickens @ZachWickens
A few years ago, we uncovered an unusual Z-selective allylic functionalization. We had no idea whatsoever how it worked. Karina and @AchyutRanjanGo1 teamed up to map out the full mechanism and identify the origin of stereoinduction!! Check out our first detailed mechanism paper!
Wickens Group @WickensGroup May 13, 2024
Finally, the mystery is solved 🕵️ We now know why allylic functionalization of alkenes via thianthrenation is Z-selective! In collaboration with the Gutierrez group, we uncovered a rare example of stereoselective deprotonation. Now at JACS! tinyurl.com/t4rkkru3
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Zach Wickens @ZachWickens
This was a lot of fun to put together with
the pioneers in this area from my group. We hope this minireview can help you think about how to use alkene thianthrenation in synthesis and why you should! Hope you enjoy it!
Wickens Group @WickensGroup Feb 8, 2024
Check out our group’s first review article-- a minireview describing how you can get to diverse cation synthons using alkene thianthrenation electrophiles! It’s been amazing to see the progress in this area! bit.ly/3usdcGc
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Zach Wickens @ZachWickens
Nice to see our alkene hydrocarboxylation getting use out in the wild! 🤩😍

Congrats to the authors on this awesome synthesis!
J. Am. Chem. Soc. @J_A_C_S Jan 7, 2024
Enantioselective Total Synthesis of (−)-Daphenylline | Journal of the American Chemical Society @CHNSci @TotalSynthesis @TotalSyntheses #Enantioselective #TotalSynthesis #Daphenylline pubs.acs.org/doi/10.1021/ja…
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Zach Wickens @ZachWickens
Super excited to see us move into new classes of reactive intermediates with potent photoreductant chemistry! Congrats to all the authors! @thechestersang @SaraAlektiar @nickcowper @jennifer_sowin
Wickens Group @WickensGroup Sep 7, 2023
Check out our latest work @J_A_C_S leveraging electrophotocatalysis to access ketyl radicals! We found polycyclic aromatic hydrocarbons are a uniquely competent class of catalysts, which enabled our group's first non-fragmentation based reduction strategy bit.ly/48j9E8v
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