alex zaharakis microbiome physicist ASD Researcher
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Autism & Microbiome Researcher
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Radiation Physicist
Real Feasible Practical Solutions Now
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Radiation Physicist
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Did you know that leucovorin has both forms (right and left handed isomers), and only one of them is usable by the body, the other builds up in the body and has a half life of 7-8 hours and actually competes with binding to the folate receptors with the left handed version that the body uses. The result is that you give a quick dose of usable left handed version.. but sustained version (right handed) that is unusable sits around afterwards and inhibits your body from using the folinic acid that is usable after that point (from dietary purposes or the versions made from bacteria in your gut). This effect is amplified at higher doses...
Did you know that leucovorin has both forms (right and left handed isomers), and only one of them is usable by the body, the other builds up in the body and has a half life of 7-8 hours and actually competes with binding to the folate receptors with the left handed version that the body uses. The result is that you give a quick dose of usable left handed version.. but sustained version (right handed) that is unusable sits around afterwards and inhibits your body from using the folinic acid that is usable after that point (from dietary purposes or the versions made from bacteria in your gut). This effect is amplified at higher doses...
What happens when 25mg Leucovorin doesn't work? Put them on 50mg.. What happens when that doesn't work? Put them on 100mg? What happens when the FRA test comes back negative.. Put them on Leucovorin.. Insane.. This is the only tool in your tool box and your completely abusing it and for $1500 consults??? WTF is going on.
Do they realize this?--> Oncology and pharmaceutical guidelines note that the apparent bioavailability of oral leucovorin is 97% for a 25 mg dose, but falls sharply to 37% for a 100 mg
Do they understand that these doses feed clostridium and pseudoclostridium Overgrowths??
Do they realize that FRA is caused from intestinal permeability in the first place and can be reversed or significantly mitigated with with Microbiome Balancing?
Do they realize that important genus like bifidobacterium is a significant producer of folate.
Does anyone even check for MTHFS mutations?
We are now seeing recommendations for 200mg of leucovorin in a single day. Kids regressing on these doses.. This is insane.
Not anti leucovorin.. this is just getting ridiculous.
Do they realize this?--> Oncology and pharmaceutical guidelines note that the apparent bioavailability of oral leucovorin is 97% for a 25 mg dose, but falls sharply to 37% for a 100 mg
Do they understand that these doses feed clostridium and pseudoclostridium Overgrowths??
Do they realize that FRA is caused from intestinal permeability in the first place and can be reversed or significantly mitigated with with Microbiome Balancing?
Do they realize that important genus like bifidobacterium is a significant producer of folate.
Does anyone even check for MTHFS mutations?
We are now seeing recommendations for 200mg of leucovorin in a single day. Kids regressing on these doses.. This is insane.
Not anti leucovorin.. this is just getting ridiculous.