adam grieve

What if a membrane protein’s movement is as important as what it does?

Our latest work reveals the unrestricted lateral mobility of a rhomboid protease enables neuronal synapse remodelling tinyurl.com/yk6xfxzr

All credit to @annabodzeta.bsky.social for this stunning work!

Add our 1st pre-print to your reading list? Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony and Robin! Plz share: tinyurl.com/3h8r7f5y

Pls RT! There's a postdoc job going to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply by 23 April: jobs.ac.uk/job/DMO097/res…. If interested, contact me and check out grieve-lab.com!

Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c

Interested in:
- mitochondrial regulation and quality control related to Parkinson's Disease?
- novel hemi-channels for mitochondrial protein import/degradation?
- the structural basis of PINK1 recognition by PARL?
Then read @JamesLorriman's cool paper! tinyurl.com/2hhp5h35