Adrian Bracken

@adrianbracken

Professor of Chromatin Biology

Trinity College Dublin brackenlab.com Joined March 2009

796 Following 1K Followers 268 Posts

Latest posts 5

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Adrian Bracken @adrianbracken Oct 31, 2025

1/ 🚀 AEBP2 isn’t what we thought.

You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity.

Excited to share our new paper surl.li/cgwqcq

A thread 🧵

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Adrian Bracken @adrianbracken May 8

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Adrian Bracken @adrianbracken Nov 27, 2025

For the love of frontier research, or why Elon’s rockets keep blowing up | EMBO reports embopress.org/doi/full/10.10…

link.springer.com For the love of frontier research, or why Elon’s rockets keep blowing up EMBO Reports - The current Zeitgeist favouring utilitarian research risks undermining basic research—the very foundation on which innovative technological advances depend.

Adrian Bracken @adrianbracken May 21, 2025

Check out this 🧵from @EimearLagan on our new @MolecularCell paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇

Eimear Lagan @EimearLagan May 21, 2025

Excited to share our new paper out today in @MolecularCell! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).

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Adrian Bracken @adrianbracken Jan 14, 2025

Please see 🧵by @evan_healy4 about our new paper exploring the role of PRC1 and PRC2 in non-dividing cells 👇

Evan Healy @evan_healy4 Jan 14, 2025

🧵 1/ We’re excited to share that our new paper with @adrianbracken lab is out 🎉 In this study (which began 10 years ago!) we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇
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