Andrew Marderstein

@amarderstein

Human geneticist @MSKCancerCenter. Postdoc @stanford, PhD @WeillCornell, BS @Cornell. Ex-Career Development chair @GeneticsSociety, Skier, Runner.

New York, NY drewmard.github.io Joined May 2013

464 Following 556 Followers 804 Posts

Latest posts 5

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Andrew Marderstein @amarderstein Jun 15

Excited to share our latest in Nature Genetics with @soumyakundu_ @anshulkundaje and Stephen Montgomery !

We built a resource of predicted variant effects on chromatin accessibility, and FLARE to identify disease variants with extreme regulatory effects.

nature.com/articles/s4158…

www.nature.com Decoding common and rare noncoding variant effects across cellular and developmental contexts Nature Genetics - This study contributes a resource of predicted effects of noncoding variants on chromatin accessibility and a method to identify noncoding variants with extreme regulatory...

Andrew Marderstein @amarderstein Aug 21

Excited and honored to have been elected last week to the ASHG Board of Directors! @GeneticsSociety

I’m excited to continue to support the next generation of geneticists, and help shape the future of human genetics. Thank you to everyone who supported me.

Andrew Marderstein @amarderstein Jun 26

Stephen Montgomery and I wrote a Research Briefing on our recent Nature Genetics paper! We summarize the study, along with some behind-the-scenes thoughts on how the project came together and what we learned along the way.
nature.com/articles/s4158…

www.nature.com Non-coding variant prioritization based on cell type, developmental stage and evolutionary constr... Nature Genetics - By using deep learning sequence models, we predict non-coding variant effects across the allele frequency spectrum in over 100 fetal and adult cell types. Linking these data with...

Andrew Marderstein @amarderstein Jun 15

Excited to share our latest in Nature Genetics with @soumyakundu_ @anshulkundaje and Stephen Montgomery !

We built a resource of predicted variant effects on chromatin accessibility, and FLARE to identify disease variants with extreme regulatory effects.

nature.com/articles/s4158…
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Andrew Marderstein @amarderstein Feb 19, 2025

New preprint w/ @soumyakundu_, @anshulkundaje, & Stephen Montgomery!

Using deep learning & scATAC-seq, we studied context-specific variants in disease & evolution, and introduce FLARE for de novo mutations—with application to autism-affected families.

doi.org/10.1101/2025.0…

Andrew Marderstein @amarderstein Feb 6, 2025

Submissions for ASHG 2025’s Featured Symposium are due Feb 10 at 5:00 pm ET!

Let me know if you have any questions. We're excited to see a wide range of proposals, ranging from AI/ML applications, clinical genetics, women's health, and more.

ashg.org/meetings/2025m…