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Andrew C. Yang

@andcyang

Assistant Professor @ UCSF & Gladstone. Solving the blood-brain barrier.
San Francisco, California, USA yanglab-ucsf.org Joined July 2020
398 Following 872 Followers 48 Posts

Latest posts 3

Andrew C. Yang @andcyang
What if the blood-brain barrier were more than a barrier?

Led by Haoyue @zho30045, we mapped the BBB transportome: diverse blood proteins imported and routed for brain health.

This peripheral support withdraws early in Alzheimer’s models, and restoring APOA1 rescued dysfunction
Labeled blood plasma proteins (white) trace BBB vessels and cross to enter an astrocyte (magenta). Cell nuclei (blue).
Haoyue Zhou @zho30045 1d
Excited to share our work from the @andcyang lab, now out in @CellCellPress! 🧵 1/7
We asked what the blood-brain barrier lets in, not just what it blocks. It turns out to import neuroprotective blood proteins, and Alzheimer’s models lose this early. 🔗 cell.com/cell/fulltext/…
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3 replies 7 reposts 41 likes 1.3K views View on X
Andrew C. Yang @andcyang
How does the brain wash its waste?

Excited to share @NaliniRRao and Yuichi's study tracking neuronal proteins from creation to clearance.

Proteins drain to their nearest exit, reaching immune niches like a zip code. AD blocks this.

w/ @ilginkolabas, @erturklab, Yadong, et al.
Nalini Rao @NaliniRRao May 29
Excited to share my first postdoc work co-led with Yuichi Chayama, from @andcyang lab - now out in @CellCellPress! We created a genetic system to trace how the brain clears waste, uncovering surprising new biology about waste clearance pathways. 🧵1/9

🔗 cell.com/cell/fulltext/…
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Andrew C. Yang @andcyang
Excited to share our preprint revealing the molecular basis of the human brain vasculature in health and Alzheimer’s disease.
From @wysscoray lab, in collab with R Vest, @fabiankern13, @SiegenthalerLab, A Keller & others. Big thanks also to #cshlbbb! 1/11
biorxiv.org/content/10.110…
www.biorxiv.org A human brain vascular atlas reveals diverse cell mediators of Alzheimer’s disease risk The human brain vasculature is of vast medical importance: its dysfunction causes disability and death, and the specialized structure it forms—the blood-brain barrier—impedes treatment of nearly all...