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Animal Genomics ETH Zurich

@animal_eth

To learn more about our research, publications and other activities, please visit our website: ag.ethz.ch
Joined December 2020
30 Following 235 Followers 121 Posts

Latest posts 5

Animal Genomics ETH Zurich @animal_eth
That was a hugely surprising finding - The Friesian POLLED haplotype has undesirable effects on mammary gland morphology in cattle

biorxiv.org/content/10.110…
www.biorxiv.org Across-breed analyses of genome-wide association studies for stature and mammary gland morphology... Background Genome-wide association studies (GWAS) in cattle populations have traditionally relied on progeny-derived phenotypes such as estimated breeding values (EBVs) as input phenotypes to...
Animal Genomics ETH Zurich @animal_eth
Structural variants are important! However, genotyping them accurately remains a challenge. We've sequenced 120 bulls with HiFi reads to investigate the contribution of structural variants to complex traits.

biorxiv.org/content/10.110…
www.biorxiv.org Structural variants are enriched for molecular QTL in a cattle long read cohort Sequencing mapping cohorts with long-read technology is crucial to understand the impact of structural variants (SVs) on complex traits. Here, we obtained 4.86 terabases of HiFi reads with an average...
Animal Genomics ETH Zurich @animal_eth
Excited to share our latest preprint, which quantifies the impact of inbreeding depression on height in Brown Swiss cattle. Using non-additive association testing, we also identify a recessive loss-of-function allele that contributes to this phenomenon.

biorxiv.org/content/10.110…
www.biorxiv.org Evidence of inbreeding depression on stature in Brown Swiss cattle Background Small effective population size and the disproportionately large use of few genetically superior bulls in artificial insemination lead to extensive runs of homozygosity and an increased...
Animal Genomics ETH Zurich @animal_eth
Our paper reporting on a pangenome-wide association testing approach just published in advance in the LRS special collection of @genomeresearch (genome.cshlp.org/content/early/…)

Thanks to all involved!
@usys_ethzh @FGCZ_EN @PacBio @IcyHawaiian
Animal Genomics ETH Zurich @animal_eth Sep 11, 2024
En route to pangenome-wide association testing - in our preprint we introduce a method to conduct association tests for binary traits directly from a pangenome graph:

biorxiv.org/content/10.110…
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