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AntoranLab

@AntoranLab

CRUK-RadNet and ARAID IIS Aragon labs.
Cell competition mechanisms, Clinical responses and Tumour development/evolution using 3D human Epithelioids
Cambridge, UK and Zaragoza, ES gurdon.cam.ac.uk/people/david-f… Joined May 2020
465 Following 596 Followers 356 Posts

Latest posts 5

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AntoranLab @AntoranLab
🚨#Preprint alert!
@antoranlab in close collaboration with @imartincorena lab

How can we study human #epithelial tissues for months in the lab, while preserving their native structures and behaviour but without passaging?

biorxiv.org/content/10.648…
www.biorxiv.org Human 3D epithelioids enable continuous long-term clonal evolution studies across multiple epithe... Modeling human epithelia in vitro remains challenging because current systems do not fully preserve the combination of architecture, heterogeneity, clonal composition, and long-term dynamics shown in...
AntoranLab @AntoranLab
"Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species"

science.org/doi/10.1126/sc…
www.science.org Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes. Emerging data...
AntoranLab @AntoranLab
"An expanded codebook of human transcription factor DNA-binding specificity"

nature.com/articles/s4158…
www.nature.com An expanded codebook of human transcription factor DNA-binding specificity Nature - Results from a panel of assays that analyse different aspects of DNA sequence specificity reveal more than 100 new motifs to aid the characterization of putative human transcription factors.
AntoranLab @AntoranLab
🎉🎉Our preprint on human #epithelioids is finally out!!

A continuous long-term, self-maintaining 3D culture platform that preserves human epithelial architecture, function and clonal diversity over months, opening new ways to study tissue biology and somatic evolution.
David F. Antoran @LupinCambridge Jun 10
🚨#Preprint alert! @antoranlab in close collaboration with @martincorena lab

How can we study human #epithelial tissues for months in the lab, while preserving their native structures and behaviour but without passaging?

#human #epithelioids

biorxiv.org/content/10.648…
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