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APL Bioengineering

@aplbioeng

A leading open access journal from @AIP_Publishing for the Bioengineering and Biomedical Research Communities EIC: @JustinCooperWh1
pubs.aip.org/aip/apb Joined September 2022
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APL Bioengineering @aplbioeng
Lee et al used a brain-on-a-chip model to show that in Alzheimer’s, toxic tau protein makes brain support cells (astrocytes) overly contract, squeezing vessels and blocking brain waste clearance.

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aippub.org/4eHGqU0
pubs.aip.org Astrocyte-driven vasoconstriction impairs glymphatic clearance in a human tauopathy-on-chip model The glymphatic system is a critical pathway for clearing metabolic waste from the brain by mediating cerebrospinal fluid and interstitial fluid exchange. In Alz
APL Bioengineering @aplbioeng
The study uses an organ-chip to reveal how shear stress regulates inflammation in arterial endothelial cells and involvement of primary cilia and YAP as therapeutic targets for atherosclerosis.

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aippub.org/44AczZ7
pubs.aip.org Pulsatile low shear stress increases susceptibility to endothelial inflammation via upregulation of... This study describes the development of a microfluidic chip model of the coronary artery endothelium and its use to examine the mechanism through which pulsatil