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Francesco Costa

@atsoCF

PhD student at Alex Bateman's group, EBI
Joined October 2021
120 Following 29 Followers 24 Posts

Latest posts 4

Francesco Costa @atsoCF
Check out this article about my research at @emblebi where I focus on protein modelling and on the study of fibrillar adhesins. Recently, we developed a method to detect isopeptide bonds, a key stabilizing feature in bacterial proteins. Big thanks to @oanastroe123!!👇
Meet Francesco Costa @atsoCF 🇮🇹 – a PhD student at EMBL-EBI, focusing on protein science.

Francesco is fascinated by protein design, and his recent work helped ‘rescue’ low-confidence #AlphaFold protein structure predictions.

embl.org/news/people-pe…

#PhD
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Francesco Costa @atsoCF
Excited to announce our latest publication: “Keeping it in the family: Using protein family templates to rescue low confidence AlphaFold2 models” where we explore plDDT variability in #AF2 models of @PfamDB domains. doi.org/10.1093/bioadv… 1/7
academic.oup.com Keeping it in the family: using protein family templates to rescue low confidence AlphaFold2 models AbstractMotivation. High confidence structure prediction models have become available for nearly all protein sequences. More than 200 million AlphaFold2 mo
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Francesco Costa @atsoCF
Feature 932 appears to associate with Asn involved in isopeptide bonds. Very cool work! (PDB IDs: 4OFQ, 2OKM, 1AMX)
Liam Bai Verified account @liambai21 Nov 14, 2024
Nonetheless, we’re excited to have deciphered (to some extent) the missing cysteine feature.

But we have so many questions…

If you’re interested in playing around with our SAE features, they’re all available at interprot.com.
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