Nabieh Ayoub Lab

Thrilled to share our manuscript identifying C8orf33 as a novel regulator of DSB repair choice. It channels repair to NHEJ over HR by antagonizing KAT8-mediated H4K16ac. Consequently, C8orf33 loss causes excessive HR, rDNA instability and cell death. 
nature.com/articles/s4141…

Excited to share our recent Spotlight at @MolecularCell highlighting how metabolite microenvironment shapes cancer treatment strategies. Thanks to Alma and Enas for their invaluable contribution @abarisaac @EZhayia

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Thrilled to share our latest article in Trends in Genetics!
Ever wondered why RNA processing factors are recruited to DNA DSBs?
We propose two explanations that shed novel insights into the functional significance of RNA processing factors at DSB sites.
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Join the Ayoub Lab at the Technion!
We are seeking motivated Master's and PhD students.
Our lab focuses on unraveling the mysteries of DNA damage repair and developing innovative targeted cancer therapies.
To apply please contact: Prof. Nabieh Ayoub: ayoubn@technion.ac.il

We are thrilled to share our discovery about targeting RBM10-deficiencey in lung adenocarcinoma (LUAD). We revealed a novel role of RBM10 in fine-tuning DNA replication and provide therapeutic arsenal for targeting RBM10-deficient tumors.
nature.com/articles/s4146…
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